ZFIN is now using GRCz12tu for Genomic Data
Gene
hcn1
- ID
- ZDB-GENE-110520-1
- Name
- hyperpolarization activated cyclic nucleotide-gated potassium channel 1
- Symbol
- hcn1 Nomenclature History
- Previous Names
-
- hc5 (1)
- si:ch73-230k7.1
- zmp:0000000818
- Type
- protein_coding_gene
- Location
- Chr: 21 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable voltage-gated potassium channel activity. Acts upstream of or within neuron-neuron synaptic transmission and posterior lateral line neuromast hair cell development. Predicted to be located in plasma membrane. Predicted to be part of HCN channel complex. Predicted to be active in axon and dendrite. Is expressed in neuromast hair cell.
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Trapani et al., 2011
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Thyme et al., 2019
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-hcn1 | Thyme et al., 2019 | |
| CRISPR2-hcn1 | Thyme et al., 2019 | |
| CRISPR3-hcn1 | Han et al., 2022 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| developmental and epileptic encephalopathy 24 | Alliance | Developmental and epileptic encephalopathy 24 | 615871 |
| generalized epilepsy with febrile seizures plus 10 | Alliance | Generalized epilepsy with febrile seizures plus, type 10 | 618482 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR018488 | Cyclic nucleotide-binding, conserved site |
| Domain | IPR000595 | Cyclic nucleotide-binding domain |
| Domain | IPR005821 | Ion transport domain |
| Domain | IPR013621 | Ion transport N-terminal |
| Family | IPR003938 | Potassium channel, voltage-dependent, EAG/ELK/ERG-like |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Cyclic nucleotide-binding, conserved site | Cyclic nucleotide-binding domain | Cyclic nucleotide-binding domain superfamily | Ion transport domain | Ion transport N-terminal | Potassium channel, voltage-dependent, EAG/ELK/ERG-like | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel | RmlC-like jelly roll fold |
|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0AB32TAQ9 | InterPro | 925 | ||||||||
| UniProtKB:A0AB32TFK5 | InterPro | 671 | ||||||||
| UniProtKB:A0A0R4IRW0 | InterPro | 908 | ||||||||
| UniProtKB:A0A8M2BGT7 | InterPro | 654 | ||||||||
| UniProtKB:A0A8M9PIR0 | InterPro | 645 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-230K7 | ZFIN Curated Data | |
| Contained in | BAC | CH211-195E10 | ZFIN Curated Data | |
| Contained in | BAC | CH211-203M19 | ZFIN Curated Data |
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| Type | Accession # | Genome Assembly | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_068215994 (1) | GRCz12tu | 4856 nt | |
| Genomic | GenBank:BX548051 (1) | 162546 nt | ||
| Polypeptide | UniProtKB:A0AB32TAQ9 (1) | 925 aa |
- Han, R., Jin, M., Xu, G., He, J. (2022) Progressively Decreased HCN1 Channels Results in Cone Morphological Defects in Diabetic Retinopathy. The Journal of neuroscience : the official journal of the Society for Neuroscience. 42(43):8200-8212
- von der Heyde, B., Emmanouilidou, A., Mazzaferro, E., Vicenzi, S., Höijer, I., Klingström, T., Jumaa, S., Dethlefsen, O., Snieder, H., de Geus, E., Ameur, A., Ingelsson, E., Allalou, A., Brooke, H.L., den Hoed, M. (2020) Translating GWAS-identified loci for cardiac rhythm and rate using an in vivo image- and CRISPR/Cas9-based approach. Scientific Reports. 10:11831
- Thyme, S.B., Pieper, L.M., Li, E.H., Pandey, S., Wang, Y., Morris, N.S., Sha, C., Choi, J.W., Herrera, K.J., Soucy, E.R., Zimmerman, S., Randlett, O., Greenwood, J., McCarroll, S.A., Schier, A.F. (2019) Phenotypic Landscape of Schizophrenia-Associated Genes Defines Candidates and Their Shared Functions. Cell. 177(2):478-491.e20
- Ramasamy, S., Sharma, S., Iyengar, B.R., Vellarikkal, S.K., Sivasubbu, S., Maiti, S., Pillai, B. (2018) Identification of novel circadian transcripts in the zebrafish retina. The Journal of experimental biology. 222(Pt 1):
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Baraban, S.C., Dinday, M.T., and Hortopan, G.A. (2013) Drug screening in Scn1a zebrafish mutant identifies clemizole as a potential Dravet syndrome treatment. Nature communications. 4:2410
- Trapani, J.G., and Nicolson, T. (2011) Mechanism of spontaneous activity in afferent neurons of the zebrafish lateral-line organ. The Journal of neuroscience : the official journal of the Society for Neuroscience. 31(5):1614-1623
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