Gene
slc16a6a
- ID
- ZDB-GENE-110208-1
- Name
- solute carrier family 16 member 6a
- Symbol
- slc16a6a Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Ambiguous Mapping Details/Browsers
- Description
- Enables monocarboxylic acid transmembrane transporter activity. Predicted to be involved in organic acid transport and organic anion transport. Predicted to act upstream of or within transmembrane transport. Predicted to be located in basolateral plasma membrane. Predicted to be active in plasma membrane. Is expressed in head; intestinal bulb; liver; pronephros; and swim bladder. Orthologous to human SLC16A6 (solute carrier family 16 member 6).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 4 figures from Hugo et al., 2012
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Allele | Type | Localization | Consequence | Mutagen | Supplier |
---|---|---|---|---|---|
s951 | Allele with one insertion | Unknown | Unknown | spontaneous |
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No data available
Human Disease
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Domain | IPR020846 | Major facilitator superfamily domain |
Family | IPR011701 | Major facilitator superfamily |
Family | IPR030766 | Monocarboxylate transporter 7 |
Family | IPR050327 | Proton-linked Monocarboxylate Transporter |
Homologous_superfamily | IPR036259 | MFS transporter superfamily |
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Domain Details Per Protein
Protein | Additional Resources | Length | Major facilitator superfamily | Major facilitator superfamily domain | MFS transporter superfamily | Monocarboxylate transporter 7 | Proton-linked Monocarboxylate Transporter |
---|---|---|---|---|---|---|---|
UniProtKB:A0A0R4IHG0 | InterPro | ||||||
UniProtKB:H6WYF6 | InterPro | 495 | |||||
UniProtKB:A0A8M3AX51 | InterPro | 340 |
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Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
---|---|---|---|---|---|
mRNA |
slc16a6-204
(1)
|
Ensembl | 1,670 nt | ||
ncRNA |
slc16a6a-002
(1)
|
Ensembl | 667 nt | ||
ncRNA |
slc16a6a-003
(1)
|
Ensembl | 556 nt | ||
pseudogenic transcript |
fp885542.2-201
(1)
|
Ensembl | 3,169 nt |
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Interactions and Pathways
No data available
Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
---|---|---|---|---|---|---|---|
Ab1-slc16a6a | polyclonal | Rabbit |
|
1 |
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Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | DKEY-106L8 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_001256832 (1) | 1676 nt | ||
Genomic | GenBank:FP885542 | 64431 nt | ||
Polypeptide | UniProtKB:H6WYF6 (1) | 495 aa |
- Karampelias, C., Watt, K., Mattsson, C.L., Ruiz, Á.F., Rezanejad, H., Mi, J., Liu, X., Chu, L., Locasale, J.W., Korbutt, G.S., Rovira, M., Larsson, O., Andersson, O. (2022) MNK2 deficiency potentiates β-cell regeneration via translational regulation. Nature Chemical Biology. 18(9):942-953
- Karanth, S., Schlegel, A. (2019) The Monocarboxylate Transporter SLC16A6 Regulates Adult Length in Zebrafish and Is Associated With Height in Humans. Frontiers in Physiology. 9:1936
- Singh, S.P., Janjuha, S., Hartmann, T., Kayisoglu, Ö., Konantz, J., Birke, S., Murawala, P., Alfar, E.A., Murata, K., Eugster, A., Tsuji, N., Morrissey, E.R., Brand, M., Ninov, N. (2017) Different developmental histories of beta-cells generate functional and proliferative heterogeneity during islet growth. Nature communications. 8:664
- Williams, L.M., Lago, B.A., McArthur, A.G., Raphenya, A.R., Pray, N., Saleem, N., Salas, S., Paulson, K., Mangar, R.S., Liu, Y., Vo, A.H., Shavit, J.A. (2016) The transcription factor, Nuclear factor, erythroid 2 (Nfe2), is a regulator of the oxidative stress response during Danio rerio development. Aquatic toxicology (Amsterdam, Netherlands). 180:141-154
- Asaoka, Y., Terai, S., Sakaida, I., and Nishina, H. (2013) The expanding role of fish models in understanding non-alcoholic fatty liver disease. Disease models & mechanisms. 6(4):905-914
- Karanth, S., Tran, V.M., Kuberan, B., and Schlegel, A. (2013) Polyunsaturated fatty acyl-coenzyme As are inhibitors of cholesterol biosynthesis in zebrafish and mice. Disease models & mechanisms. 6(6):1365-77
- Nguyen, M., Yang, E., Neelkantan, N., Mikhaylova, A., Arnold, R., Poudel, M.K., Stewart, A.M., and Kalueff, A.V. (2013) Developing 'integrative' zebrafish models of behavioral and metabolic disorders. Behavioural brain research. 256C:172-187
- Hugo, S.E., Cruz-Garcia, L., Karanth, S., Anderson, R.M., Stainier, D.Y., and Schlegel, A. (2012) A monocarboxylate transporter required for hepatocyte secretion of ketone bodies during fasting. Genes & Development. 26(3):282-93
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