Gene
cyp17a2
- ID
- ZDB-GENE-100822-1
- Name
- cytochrome P450, family 17, subfamily A, polypeptide 2
- Symbol
- cyp17a2 Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 23 Mapping Details/Browsers
- Description
- Enables steroid 17-alpha-monooxygenase activity. Acts upstream of or within progesterone metabolic process. Predicted to be located in endoplasmic reticulum membrane. Is expressed in brain and endocrine system. Human ortholog(s) of this gene implicated in several diseases, including cholelithiasis; congenital adrenal hyperplasia; gallbladder cancer; osteoporosis; and prostate cancer. Orthologous to human CYP17A1 (cytochrome P450 family 17 subfamily A member 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 14 figures from 10 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 6 figures from Shi et al., 2022
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Cytochrome P450 | Cytochrome P450, conserved site | Cytochrome P450, E-class, group I | Cytochrome P450 superfamily |
|---|---|---|---|---|---|---|
| UniProtKB:A7U483 | InterPro PDB | 495 | ||||
| UniProtKB:A0AB32TFV6 | InterPro | 390 | ||||
| UniProtKB:A0AB32TJ29 | InterPro | 380 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
cyp17a2-201
(1)
|
Ensembl | 1,488 nt | ||
| ncRNA |
cyp17a2-002
(1)
|
Ensembl | 341 nt |
Interactions and Pathways
No data available
Plasmids
No data available