Gene
exoc3l2b
- ID
- ZDB-GENE-100728-5
- Name
- exocyst complex component 3-like 2b
- Symbol
- exoc3l2b Nomenclature History
- Previous Names
-
- exoc3l2
- sec6 (1)
- Type
- protein_coding_gene
- Location
- Chr: 15 Mapping Details/Browsers
- Description
- Predicted to enable SNARE binding activity. Predicted to be involved in exocyst localization and exocytosis. Predicted to be part of exocyst. Is expressed in hindbrain; neural crest; and pharyngeal arch. Orthologous to human EXOC3L2 (exocyst complex component 3 like 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from Piloto et al., 2010
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Allele | Type | Localization | Consequence | Mutagen | Supplier |
---|---|---|---|---|---|
sa14042 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa35865 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa35866 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa42527 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa42528 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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Targeting Reagent | Created Alleles | Citations |
---|---|---|
MO1-exoc3l2b | N/A | Bielczyk-Maczyńska et al., 2014 |
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Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
Brain malformation renal syndrome | 620943 |
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Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Additional Resources | Length | Exocyst complex component EXOC3/Sec6 | Exocyst complex component EXOC3/Sec6, C-terminal domain |
---|---|---|---|---|
UniProtKB:A0A8M3B147 | InterPro | 917 | ||
UniProtKB:A0A8M9Q5H9 | InterPro | 917 | ||
UniProtKB:E7EY52 | InterPro | 861 |
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Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
---|---|---|---|---|---|
mRNA |
exoc3l2b-201
(1)
|
Ensembl | 2,586 nt | ||
mRNA |
exoc3l2b-202
(1)
|
Ensembl | 3,133 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | CH211-51K14 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:XM_021472940 (1) | 5708 nt | ||
Genomic | GenBank:BX005374 (1) | 204318 nt | ||
Polypeptide | UniProtKB:A0A8M3B147 (1) | 917 aa |
- Comparative Orthology
- Alliance
- Lang, I., Virk, G., Zheng, D.C., Young, J., Nguyen, M.J., Amiri, R., Fong, M., Arata, A., Chadaideh, K.S., Walsh, S., Weiser, D.C. (2020) The Evolution of Duplicated Genes of the Cpi-17/Phi-1 (ppp1r14) Family of Protein Phosphatase 1 Inhibitors in Teleosts. International Journal of Molecular Sciences. 21(16):
- Braasch, I., Gehrke, A.R., Smith, J.J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A.M., Campbell, M.S., Barrell, D., Martin, K.J., Mulley, J.F., Ravi, V., Lee, A.P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F.E., Sun, Y., Hertel, J., Beam, M.J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J.H., Litman, G.W., Litman, R.T., Mikami, M., Ota, T., Saha, N.R., Williams, L., Stadler, P.F., Wang, H., Taylor, J.S., Fontenot, Q., Ferrara, A., Searle, S.M., Aken, B., Yandell, M., Schneider, I., Yoder, J.A., Volff, J.N., Meyer, A., Amemiya, C.T., Venkatesh, B., Holland, P.W., Guiguen, Y., Bobe, J., Shubin, N.H., Di Palma, F., Alföldi, J., Lindblad-Toh, K., Postlethwait, J.H. (2016) The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nature Genetics. 48(4):427-37
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Bielczyk-Maczyńska, E., Serbanovic-Canic, J., Ferreira, L., Soranzo, N., Stemple, D.L., Ouwehand, W.H., Cvejic, A. (2014) A loss of function screen of identified genome-wide association study Loci reveals new genes controlling hematopoiesis. PLoS Genetics. 10:e1004450
- Piloto, S., and Schilling, T.F. (2010) Ovo1 links Wnt signaling with N-cadherin localization during neural crest migration. Development (Cambridge, England). 137(12):1981-1990
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