Gene

bcl10

ID

ZDB-GENE-100219-2

Name

BCL10 immune signaling adaptor

Symbol

bcl10 Nomenclature History

Previous Names

None

Type

protein_coding_gene

Location

Chr: 2 Mapping Details/Browsers

Description

Involved in positive regulation of NF-kappaB transcription factor activity. Localizes to CBM complex. Human ortholog(s) of this gene implicated in MALT lymphoma; malignant mesothelioma; non-Hodgkin lymphoma; and primary immunodeficiency disease. Is expressed in gill; intestine; male organism; and spleen. Orthologous to human BCL10 (BCL10 immune signaling adaptor).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

3 figures from 3 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With bcl10 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue	Alliance	Lymphoma, MALT, somatic	137245
immunodeficiency 37	Alliance	?Immunodeficiency 37	616098
malignant mesothelioma	Alliance	{Mesothelioma, somatic}	156240
non-Hodgkin lymphoma	Alliance	{Lymphoma, follicular, somatic}	605027
testicular germ cell cancer	Alliance	{Male germ cell tumor, somatic}	273300
		{Sezary syndrome, somatic}

Associated With bcl10 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR001315	CARD domain
Domain	IPR042143	BCL10, CARD domain
Family	IPR033238	B-cell lymphoma/leukemia 10/E10
Homologous_superfamily	IPR011029	Death-like domain superfamily

Domain Details Per Protein

Protein	Length	B-cell lymphoma/leukemia 10/E10	BCL10, CARD domain	CARD domain	Death-like domain superfamily
UniProtKB:E7F8A6 InterPro	241
UniProtKB:A0A8M9P7U3 InterPro	232

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	bcl10-201 (1) Ensembl	Havana	3859 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

Name	Type	Antigen Genes	Isotype	Host Organism	Assay	Source	Citations
Ab1-bcl10	polyclonal	bcl10	IgG	Rabbit	WB	Santa Cruz Biotechnology, Inc.	2

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations