Gene
hwa
- ID
- ZDB-GENE-091204-94
- Name
- huluwa
- Symbol
- hwa Nomenclature History
- Previous Names
-
- si:dkey-121h17.7 (1)
- Type
- protein_coding_gene
- Location
- Chr: 21 Mapping Details/Browsers
- Description
- Involved in dorsal/ventral pattern formation; embryonic axis specification; and positive regulation of canonical Wnt signaling pathway. Acts upstream of or within axis specification and regulation of canonical Wnt signaling pathway. Is active in plasma membrane. Is expressed in blastomere and oocyte stage I.
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from Yan et al., 2018
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 6 figures from Yan et al., 2018
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-hwa | Yan et al., 2018 | |
| CRISPR2-hwa | (2) |
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Human Disease
Domain, Family, and Site Summary
No data available
Domain Details Per Protein
| Protein | Additional Resources | Length |
|---|---|---|
| UniProtKB:E9QDC5 | InterPro | 294 |
| UniProtKB:A0AB13A967 | InterPro | 294 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
si:dkey-121h17.7-201
(1)
|
Ensembl | 1,515 nt |
1 - 1 of 1
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-121H17 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001423776 (1) | |||
| Genomic | GenBank:CR382296 (1) | 137360 nt | ||
| Polypeptide | UniProtKB:A0AB13A967 (1) | 294 aa |
No data available
- Li, Y., Yan, Y., Gong, B., Zheng, Q., Zhou, H., Sun, J., Li, M., Wang, Z., Li, Y., Wan, Y., Chen, W., Qi, S., Mo, X., Meng, A., Xiang, B., Chen, J. (2024) A Huluwa phosphorylation switch regulates embryonic axis induction. Nature communications. 15:1002810028
- Zebrafish Nomenclature Committee (2024) Nomenclature Data Curation (2024). Nomenclature Committee Submission.
- Zheng, Q., Wu, X., Li, X., Mo, X., Xiang, B., Chen, J. (2024) Low-input CUT&Tag for efficient epigenomic profiling of zebrafish stage I oocytes. Frontiers in cell and developmental biology. 12:14759121475912
- Xing, C., Shen, W., Gong, B., Li, Y., Yan, L., Meng, A. (2022) Maternal Factors and Nodal Autoregulation Orchestrate Nodal Gene Expression for Embryonic Mesendoderm Induction in the Zebrafish. Frontiers in cell and developmental biology. 10:887987
- Xing, C., Zeng, Z., Li, Y., Gong, B., Shen, W., Shah, R., Yan, L., Du, H., Meng, A. (2022) Regulatory factor identification for nodal genes in zebrafish by causal inference. Frontiers in cell and developmental biology. 10:1047363
- Yan, L., Chen, J., Zhu, X., Sun, J., Wu, X., Shen, W., Zhang, W., Tao, Q., Meng, A. (2018) Maternal Huluwa dictates the embryonic body axis through β-catenin in vertebrates. Science (New York, N.Y.). 362(6417)
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