ZFIN is now using GRCz12tu for Genomic Data
Gene
ap2a1
- ID
- ZDB-GENE-090302-2
- Name
- adaptor related protein complex 2 subunit alpha 1
- Symbol
- ap2a1 Nomenclature History
- Previous Names
-
- fa95c07
- si:ch211-195b15.3
- wu:fa95c07 (1)
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable clathrin adaptor activity. Acts upstream of or within convergent extension involved in axis elongation; dorsal/ventral axis specification; and hematopoietic stem cell differentiation. Predicted to be located in clathrin-coated pit. Predicted to be part of AP-2 adaptor complex. Orthologous to human AP2A1 (adaptor related protein complex 2 subunit alpha 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| autism spectrum disorder | ap2a1sa1907/sa1907 | standard conditions | Zúñiga Mouret et al., 2024 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR002553 | Clathrin/coatomer adaptor, adaptin-like, N-terminal |
| Domain | IPR003164 | Clathrin adaptor, alpha-adaptin, appendage, C-terminal subdomain |
| Domain | IPR008152 | Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain |
| Family | IPR017104 | Adaptor protein complex AP-2, alpha subunit |
| Family | IPR050840 | Adaptor Complexes Large Subunit |
| Homologous_superfamily | IPR009028 | Coatomer/calthrin adaptor appendage, C-terminal subdomain |
| Homologous_superfamily | IPR011989 | Armadillo-like helical |
| Homologous_superfamily | IPR012295 | TBP domain superfamily |
| Homologous_superfamily | IPR013041 | Clathrin adaptor, appendage, Ig-like subdomain superfamily |
| Homologous_superfamily | IPR016024 | Armadillo-type fold |
Domain Details Per Protein
| Protein | Additional Resources | Length | Adaptor Complexes Large Subunit | Adaptor protein complex AP-2, alpha subunit | Armadillo-like helical | Armadillo-type fold | Clathrin adaptor, alpha-adaptin, appendage, C-terminal subdomain | Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain | Clathrin adaptor, appendage, Ig-like subdomain superfamily | Clathrin/coatomer adaptor, adaptin-like, N-terminal | Coatomer/calthrin adaptor appendage, C-terminal subdomain | TBP domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0AB32TH56 | InterPro | 980 | ||||||||||
| UniProtKB:A0AB32TH60 | InterPro | 959 | ||||||||||
| UniProtKB:A0AB32TJW0 | InterPro | 935 | ||||||||||
| UniProtKB:A0AB32TK65 | InterPro | 959 | ||||||||||
| UniProtKB:A0AB32TP30 | InterPro | 980 | ||||||||||
| UniProtKB:A0AB32TPH2 | InterPro | 935 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers
- Comparative Orthology
- Alliance