Gene
crhr1
- ID
- ZDB-GENE-081231-1
- Name
- corticotropin releasing hormone receptor 1
- Symbol
- crhr1 Nomenclature History
- Previous Names
-
- crfr1 (1)
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Description
- Predicted to enable G protein-coupled receptor activity; corticotropin-releasing hormone binding activity; and corticotropin-releasing hormone receptor activity. Acts upstream of or within several processes, including response to cortisol; swimming behavior; and thigmotaxis. Predicted to be active in neuron projection and plasma membrane. Is expressed in several structures, including brain; gill; gonad; heart; and liver. Human ortholog(s) of this gene implicated in asthma; chronic obstructive pulmonary disease; and obesity. Orthologous to human CRHR1 (corticotropin releasing hormone receptor 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 7 figures from 6 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR017983 | GPCR, family 2, secretin-like, conserved site |
| Domain | IPR001879 | GPCR, family 2, extracellular hormone receptor domain |
| Domain | IPR017981 | GPCR, family 2-like, 7TM |
| Family | IPR000832 | GPCR, family 2, secretin-like |
| Family | IPR003051 | GPCR, family 2, corticotropin releasing factor receptor |
| Family | IPR003052 | GPCR, family 2, corticotropin releasing factor receptor, type 1 |
| Family | IPR050332 | G-protein coupled receptor 2 |
| Homologous_superfamily | IPR036445 | GPCR family 2, extracellular hormone receptor domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | GPCR, family 2, corticotropin releasing factor receptor | GPCR, family 2, corticotropin releasing factor receptor, type 1 | GPCR, family 2, extracellular hormone receptor domain | GPCR family 2, extracellular hormone receptor domain superfamily | GPCR, family 2-like, 7TM | GPCR, family 2, secretin-like | GPCR, family 2, secretin-like, conserved site | G-protein coupled receptor 2 |
|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:X1WHD4 | InterPro | 430 |
Interactions and Pathways
No data available
Plasmids