Gene
myo9ab
- ID
- ZDB-GENE-080424-6
- Name
- myosin IXAb
- Symbol
- myo9ab Nomenclature History
- Previous Names
-
- myo9a2 (1)
- myo9al2
- im:7155152
- Type
- protein_coding_gene
- Location
- Chr: 25 Mapping Details/Browsers
- Description
- Predicted to enable actin filament binding activity and microfilament motor activity. Acts upstream of or within axon extension; neuromuscular junction development, skeletal muscle fiber; and swimming behavior. Predicted to be located in several cellular components, including cytoplasm; growth cone; and synapse. Predicted to be part of myosin complex. Predicted to be active in actin filament and axonal growth cone. Human ortholog(s) of this gene implicated in congenital myasthenic syndrome. Orthologous to human MYO9A (myosin IXA).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from O'Connor et al., 2016
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from O'Connor et al., 2019
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Allele | Type | Localization | Consequence | Mutagen | Supplier |
---|---|---|---|---|---|
sa16393 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa24581 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa30171 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa37972 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa39467 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa44210 | Allele with one point mutation | Unknown | Splice Site | ENU |
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Targeting Reagent | Created Alleles | Citations |
---|---|---|
CRISPR1-myo9ab | O'Connor et al., 2019 | |
CRISPR2-myo9ab | O'Connor et al., 2019 | |
MO1-myo9ab | N/A | (2) |
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Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
Myasthenic syndrome, congenital, 24, presynaptic | 618198 |
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Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Binding_site | IPR000048 | IQ motif, EF-hand binding site |
Domain | IPR000159 | Ras-associating domain |
Domain | IPR000198 | Rho GTPase-activating protein domain |
Domain | IPR001609 | Myosin head, motor domain-like |
Domain | IPR002219 | Protein kinase C-like, phorbol ester/diacylglycerol-binding domain |
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Domain Details Per Protein
Protein | Additional Resources | Length | C1-like domain superfamily | Class IX myosin, motor domain | IQ motif, EF-hand binding site | Kinesin motor domain superfamily | Myosin head, motor domain-like | P-loop containing nucleoside triphosphate hydrolase | Protein kinase C-like, phorbol ester/diacylglycerol-binding domain | Ras-associating domain | Rho GTPase-activating protein domain | Rho GTPase activation protein | Ubiquitin-like domain superfamily | Unconventional class IX myosin |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
UniProtKB:A0AB13ABJ7 | InterPro | 2304 |
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Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
---|---|---|---|---|---|
mRNA |
myo9ab-201
(1)
|
Ensembl | 6,861 nt | ||
mRNA |
myo9ab-203
(1)
|
Ensembl | 7,584 nt | ||
ncRNA |
myo9ab-002
(1)
|
Ensembl | 497 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | Fosmid | CH1073-360M4 | ZFIN Curated Data | |
Encodes | EST | IMAGE:7155152 | Thisse et al., 2004 |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_001423784 (1) | 7178 nt | ||
Genomic | GenBank:CABZ01074930 (1) | 57974 nt | ||
Polypeptide | UniProtKB:A0AB13ABJ7 (1) | 2304 aa |
- Comparative Orthology
- Alliance
- O'Connor, E., Cairns, G., Spendiff, S., Burns, D., Hettwer, S., Mäder, A., Müller, J., Horvath, R., Slater, C., Roos, A., Lochmüller, H. (2019) Modulation of Agrin and RhoA Pathways Ameliorates Movement Defects and Synapse Morphology in MYO9A-Depleted Zebrafish. Cells. 8(8)
- O'Connor, E., Phan, V., Cordts, I., Cairns, G., Hettwer, S., Cox, D., Lochmüller, H., Roos, A. (2018) MYO9A deficiency in motor neurons is associated with reduced neuromuscular agrin secretion. Human molecular genetics. 27(8):1434-1446
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Wang, X., Lin, J., Li, F., Zhang, C., Li, J., Wang, C., Dahlgren, R.A., Zhang, H., Wang, H. (2017) Screening and functional identification of lncRNAs under β-diketone antibiotic exposure to zebrafish (Danio rerio) using high-throughput sequencing. Aquatic toxicology (Amsterdam, Netherlands). 182:214-225
- Braasch, I., Gehrke, A.R., Smith, J.J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A.M., Campbell, M.S., Barrell, D., Martin, K.J., Mulley, J.F., Ravi, V., Lee, A.P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F.E., Sun, Y., Hertel, J., Beam, M.J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J.H., Litman, G.W., Litman, R.T., Mikami, M., Ota, T., Saha, N.R., Williams, L., Stadler, P.F., Wang, H., Taylor, J.S., Fontenot, Q., Ferrara, A., Searle, S.M., Aken, B., Yandell, M., Schneider, I., Yoder, J.A., Volff, J.N., Meyer, A., Amemiya, C.T., Venkatesh, B., Holland, P.W., Guiguen, Y., Bobe, J., Shubin, N.H., Di Palma, F., Alföldi, J., Lindblad-Toh, K., Postlethwait, J.H. (2016) The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nature Genetics. 48(4):427-37
- O'Connor, E., Töpf, A., Müller, J.S., Cox, D., Evangelista, T., Colomer, J., Abicht, A., Senderek, J., Hasselmann, O., Yaramis, A., Laval, S.H., Lochmüller, H. (2016) Identification of mutations in the MYO9A gene in patients with congenital myasthenic syndrome. Brain : a journal of neurology. 139(Pt 8):2143-53
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Sittaramane, V., and Chandrasekhar, A. (2008) Expression of unconventional myosin genes during neuronal development in zebrafish. Gene expression patterns : GEP. 8(3):161-170
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