Gene

myo9ab

ID

ZDB-GENE-080424-6

Name

myosin IXAb

Symbol

myo9ab Nomenclature History

Previous Names

myo9a2 (1)
myo9al2
im:7155152

Type

protein_coding_gene

Location

Chr: 25 Mapping Details/Browsers

Description

Predicted to have several functions, including ATP binding activity; GTPase activator activity; and actin binding activity. Involved in axon extension and swimming behavior. Predicted to localize to several cellular components, including growth cone; myosin complex; and synapse. Human ortholog(s) of this gene implicated in congenital myasthenic syndrome. Orthologous to human MYO9A (myosin IXA).

Genome Resources

Note

None

Expression

All Expression Data

Fig. S2 from O'Connor et al., 2016

Cross-Species Comparison

High Throughput Data

Expression Atlas

Wild Type Expression Summary

Phenotype

All Phenotype Data: Fig. 1 from O'Connor et al., 2019
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With myo9ab Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Myasthenic syndrome, congenital, 24, presynaptic	618198

Associated With myo9ab Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Binding_site	IPR000048	IQ motif, EF-hand binding site
Domain	IPR000198	Rho GTPase-activating protein domain
Domain	IPR001609	Myosin head, motor domain
Domain	IPR002219	Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
Family	IPR028558	Unconventional myosin-IXa
Homologous_superfamily	IPR008936	Rho GTPase activation protein
Homologous_superfamily	IPR027417	P-loop containing nucleoside triphosphate hydrolase
Homologous_superfamily	IPR036961	Kinesin motor domain superfamily

Domain Details Per Protein

Protein	Length	IQ motif, EF-hand binding site	Kinesin motor domain superfamily	Myosin head, motor domain	P-loop containing nucleoside triphosphate hydrolase	Protein kinase C-like, phorbol ester/diacylglycerol-binding domain	Rho GTPase-activating protein domain	Rho GTPase activation protein	Unconventional myosin-IXa
UniProtKB:X1WE51 InterPro	1477
UniProtKB:E7F3F0 InterPro	2286

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Length (nt)	Analysis
mRNA	myo9ab-203 (1) Ensembl	7584 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
ncRNA	myo9ab-002 (1) Ensembl	497 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Ensembl Gene Tree

Citations