ZFIN is now using GRCz12tu for Genomic Data
Gene
waplb
- ID
- ZDB-GENE-080220-45
- Name
- WAPL cohesin release factor b
- Symbol
- waplb Nomenclature History
- Previous Names
-
- wapalb
- zgc:171432
- Type
- protein_coding_gene
- Location
- Chr: 12 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Orthologous to human WAPL (WAPL cohesin release factor).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa9959 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa13582 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa19030 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa35225 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa35226 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-waplb | Thomas et al., 2014 | |
| CRISPR2-waplb | Thomas et al., 2014 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Armadillo-like helical | WAPL domain | Wings apart-like protein | Wings apart-like protein, C-terminal |
|---|---|---|---|---|---|---|
| UniProtKB:A0A8M9QEL9 | InterPro | 1168 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
waplb-201
(1)
|
Ensembl | 5,475 nt | ||
| mRNA | zgc:171432-001 (1) | 5,475 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-67C24 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-257J3 | ZFIN Curated Data | |
| Has Artifact | cDNA | MGC:171432 | ZFIN Curated Data |
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| Type | Accession # | Genome Assembly | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001114932 (1) | 863 nt | ||
| Genomic | GenBank:AL929308 (1) | 168467 nt | ||
| Polypeptide | UniProtKB:A0A8M9QEL9 (1) | 1168 aa |
- Zhang, Y., Li, R., Li, H., Huang, Y., Mei, Y., Zheng, Y., Guo, Y., Zhou, Z., Yong, Z., Zhao, Y., Dong, W., Gao, J., Cao, X. (2024) Morpho-histological and Transcriptome Analysis Reveal the Unreduced Sperm Formation Mechanism in cdk1-Depletion Zebrafish. Marine biotechnology (New York, N.Y.). 26(6):1206-1218
- Braasch, I., Gehrke, A.R., Smith, J.J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A.M., Campbell, M.S., Barrell, D., Martin, K.J., Mulley, J.F., Ravi, V., Lee, A.P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F.E., Sun, Y., Hertel, J., Beam, M.J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J.H., Litman, G.W., Litman, R.T., Mikami, M., Ota, T., Saha, N.R., Williams, L., Stadler, P.F., Wang, H., Taylor, J.S., Fontenot, Q., Ferrara, A., Searle, S.M., Aken, B., Yandell, M., Schneider, I., Yoder, J.A., Volff, J.N., Meyer, A., Amemiya, C.T., Venkatesh, B., Holland, P.W., Guiguen, Y., Bobe, J., Shubin, N.H., Di Palma, F., Alföldi, J., Lindblad-Toh, K., Postlethwait, J.H. (2016) The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nature Genetics. 48(4):427-37
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Thomas, H.R., Percival, S.M., Yoder, B.K., Parant, J.M. (2014) High-Throughput Genome Editing and Phenotyping Facilitated by High Resolution Melting Curve Analysis. PLoS One. 9:e114632
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