Gene

adam19b

ID

ZDB-GENE-070705-541

Name

ADAM metallopeptidase domain 19b

Symbol

adam19b Nomenclature History

Previous Names

si:dkeyp-44a8.1

Type

protein_coding_gene

Location

Chr: 14 Mapping Details/Browsers

Description

Predicted to have SH3 domain binding activity and metalloendopeptidase activity. Predicted to be involved in membrane protein ectodomain proteolysis. Predicted to localize to Golgi apparatus and integral component of membrane. Is expressed in nervous system. Orthologous to human ADAM19 (ADAM metallopeptidase domain 19).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Cox et al., 2019

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 2 figures from Cox et al., 2019
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With adam19b Human Ortholog

No data available

Associated With adam19b Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR018358	Disintegrin, conserved site
Domain	IPR000742	EGF-like domain
Domain	IPR001590	Peptidase M12B, ADAM/reprolysin
Domain	IPR001762	Disintegrin domain
Domain	IPR002870	Peptidase M12B, propeptide
Domain	IPR006586	ADAM, cysteine-rich domain
Domain	IPR034027	Reprolysin domain, adamalysin-type
Homologous_superfamily	IPR024079	Metallopeptidase, catalytic domain superfamily
Homologous_superfamily	IPR036436	Disintegrin domain superfamily

Domain Details Per Protein

Protein	Length	ADAM, cysteine-rich domain	Disintegrin, conserved site	Disintegrin domain	Disintegrin domain superfamily	EGF-like domain	Metallopeptidase, catalytic domain superfamily	Peptidase M12B, ADAM/reprolysin	Peptidase M12B, propeptide	Reprolysin domain, adamalysin-type
UniProtKB:F1Q4N9 InterPro	923

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	adam19b-201 (1) Ensembl	Havana	4122 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	adam19b-203 (1) Ensembl	Havana	464 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
ncRNA	adam19b-001 (1) Ensembl	Havana	572 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
ncRNA	adam19b-004 (1) Ensembl	Havana	730 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations