Gene
pard6a
- ID
- ZDB-GENE-070705-215
- Name
- par-6 family cell polarity regulator alpha
- Symbol
- pard6a Nomenclature History
- Previous Names
-
- si:ch73-186j5.3
- Type
- protein_coding_gene
- Location
- Chr: 18 Mapping Details/Browsers
- Description
- Acts upstream of or within heart development and neural tube formation. Located in apical plasma membrane. Orthologous to human PARD6A (par-6 family cell polarity regulator alpha).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Minhas et al., 2021
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Minhas et al., 2021
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la020328Tg | Transgenic insertion | Unknown | Unknown | DNA |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-pard6a | N/A | Munson et al., 2008 |
| MO2-pard6a | N/A | Minhas et al., 2021 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Partitioning defective 6 homolog protein | Partitioning defective protein 6, PB1 domain | PB1 domain | PB1-like domain | PDZ domain | PDZ superfamily |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:A6YIE1 | InterPro | 385 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
pard6a-201
(1)
|
Ensembl | 3,890 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-186J5 | ZFIN Curated Data | |
| Contained in | BAC | CH211-193L7 | ZFIN Curated Data | |
| Encodes | EST | wz13456 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001100051 (1) | 1158 nt | ||
| Genomic | GenBank:BX927240 (1) | 263615 nt | ||
| Polypeptide | UniProtKB:A6YIE1 (1) | 385 aa |
- Minhas, R., Loeffler-Wirth, H., Siddiqui, Y.H., Obrębski, T., Vashisht, S., Nahia, K.A., Paterek, A., Brzozowska, A., Bugajski, L., Piwocka, K., Korzh, V., Binder, H., Winata, C.L. (2021) Transcriptome profile of the sinoatrial ring reveals conserved and novel genetic programs of the zebrafish pacemaker. BMC Genomics. 22:715
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Munson, C., Huisken, J., Bit-Avragim, N., Kuo, T., Dong, P.D., Ober, E.A., Verkade, H., Abdelilah-Seyfried, S., and Stainier, D.Y. (2008) Regulation of neurocoel morphogenesis by Pard6gammab. Developmental Biology. 324(1):41-54
- Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433
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