Gene
nostrin
- ID
- ZDB-GENE-070522-2
- Name
- nitric oxide synthase trafficking
- Symbol
- nostrin Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 9 Mapping Details/Browsers
- Description
- Acts upstream of or within several processes, including glomerular epithelium development; regulation of filopodium assembly; and sprouting angiogenesis. Predicted to be located in organelle. Orthologous to human NOSTRIN (nitric oxide synthase trafficking).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Kovacevic et al., 2012
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa9638 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa15123 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa15830 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa25441 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-nostrin | N/A | Ebarasi et al., 2009 |
| MO2-nostrin | N/A | Kovacevic et al., 2012 |
| MO3-nostrin | N/A | Kovacevic et al., 2012 |
| MO4-nostrin | N/A | Kirsch et al., 2013 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | AH/BAR domain superfamily | F-BAR domain | FCH domain | Nostrin, SH3 domain | SH3 domain | SH3-like domain superfamily |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:A8WFV6 | InterPro | 537 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
nostrin-201
(1)
|
Ensembl | 2,682 nt | ||
| mRNA |
nostrin-202
(1)
|
Ensembl | 2,578 nt |
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Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-nostrin | polyclonal | Rabbit |
|
1 |
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Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-278B7 | ||
| Encodes | cDNA | MGC:171848 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001113604 (1) | 2599 nt | ||
| Genomic | GenBank:CR626882 (1) | 162232 nt | ||
| Polypeptide | UniProtKB:A8WFV6 (1) | 537 aa |
- Kirsch, T., Kaufeld, J., Korstanje, R., Hentschel, D.M., Staggs, L., Bollig, F., Beese, M., Schroder, P., Boehme, L., Haller, H., and Schiffer, M. (2013) Knockdown of the Hypertension-Associated Gene NOSTRIN Alters Glomerular Barrier Function in Zebrafish (Danio rerio). Hypertension (Dallas, Tex. : 1979). 62(4):726-30
- Kovacevic, I., Hu, J., Siehoff-Icking, A., Opitz, N., Griffin, A., Perkins, A.C., Munn, A.L., Müller-Esterl, W., Popp, R., Fleming, I., Jungblut, B., Hoffmeister, M., and Oess, S. (2012) The F-BAR protein NOSTRIN participates in FGF signal transduction and vascular development. The EMBO journal. 31(15):3309-3322
- Ebarasi, L., He, L., Hultenby, K., Takemoto, M., Betsholtz, C., Tryggvason, K., and Majumdar, A. (2009) A reverse genetic screen in the zebrafish identifies crb2b as a regulator of the glomerular filtration barrier. Developmental Biology. 334(1):1-9
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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