Gene

nr0b1

ID
ZDB-GENE-070130-1
Name
nuclear receptor subfamily 0, group B, member 1
Symbol
nr0b1 Nomenclature History
Previous Names
  • dax1 (1)
  • DAX (1)
Type
protein_coding_gene
Location
Chr: 11 Mapping Details/Browsers
Description
Predicted to have transcription corepressor activity and transcription factor binding activity. Involved in negative regulation of male gonad development and water homeostasis. Predicted to localize to cytoplasm and nucleus. Human ortholog(s) of this gene implicated in 46,XY sex reversal 2 and X-linked adrenal hypoplasia congenita. Is expressed in several structures, including central nervous system; digestive system; fin; interrenal primordium; and reproductive system. Orthologous to human NR0B1 (nuclear receptor subfamily 0 group B member 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
17 figures from 8 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
9 figures from 3 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With nr0b1 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
46,XY sex reversal 2 Alliance 46XY sex reversal 2, dosage-sensitive 300018
X-linked adrenal hypoplasia congenita Alliance Adrenal hypoplasia, congenital 300200
Associated With nr0b1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000536 Nuclear hormone receptor, ligand-binding domain
Family IPR001723 Nuclear hormone receptor
Family IPR033544 Nuclear receptor subfamily 0 group B member 1/2
Homologous_superfamily IPR035500 Nuclear hormone receptor-like domain superfamily
Domain Details Per Protein
Protein Length Nuclear hormone receptor Nuclear hormone receptor, ligand-binding domain Nuclear hormone receptor-like domain superfamily Nuclear receptor subfamily 0 group B member 1/2
UniProtKB:A3KNP5 264
UniProtKB:F1QNF1 302
UniProtKB:Q1L693 121
Transcripts
Genome Browsers
Interactions and Pathways
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations