Gene
fto
- ID
- ZDB-GENE-061108-1
- Name
- FTO alpha-ketoglutarate dependent dioxygenase
- Symbol
- fto Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Predicted to enable broad specificity oxidative DNA demethylase activity and mRNA N6-methyladenosine dioxygenase activity. Acts upstream of or within several processes, including cilium assembly; left/right pattern formation; and positive regulation of canonical Wnt signaling pathway. Predicted to be located in cytoplasm and nuclear speck. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); diabetic neuropathy; nuclear senile cataract; renal cell carcinoma (multiple); and type 2 diabetes mellitus. Orthologous to human FTO (FTO alpha-ketoglutarate dependent dioxygenase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 5 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 4 figures from Osborn et al., 2014
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR024366 | Alpha-ketoglutarate-dependent dioxygenase FTO, C-terminal |
| Domain | IPR024367 | Alpha-ketoglutarate-dependent dioxygenase FTO, catalytic domain |
| Family | IPR032868 | Alpha-ketoglutarate-dependent dioxygenase FTO |
| Homologous_superfamily | IPR037151 | Alpha-ketoglutarate-dependent dioxygenase AlkB-like superfamily |
| Homologous_superfamily | IPR038413 | FTO, C-terminal domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Alpha-ketoglutarate-dependent dioxygenase AlkB-like superfamily | Alpha-ketoglutarate-dependent dioxygenase FTO | Alpha-ketoglutarate-dependent dioxygenase FTO, catalytic domain | Alpha-ketoglutarate-dependent dioxygenase FTO, C-terminal | FTO, C-terminal domain superfamily |
|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M1PZX3 | InterPro | 579 | |||||
| UniProtKB:A0A8M9PKY4 | InterPro | 580 | |||||
| UniProtKB:A0A8M9PS12 | InterPro | 579 |
Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-fto | monoclonal | IgG | Mouse |
|
PhosphoSolutions
|
1 |
Plasmids
No data available