ZFIN is now using GRCz12tu for Genomic Data
Gene
manf
- ID
- ZDB-GENE-060929-640
- Name
- mesencephalic astrocyte-derived neurotrophic factor
- Symbol
- manf Nomenclature History
- Previous Names
-
- im:6909481
- zgc:153327
- Type
- protein_coding_gene
- Location
- Chr: 22 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable growth factor activity. Acts upstream of or within dopaminergic neuron differentiation. Predicted to be located in extracellular region. Predicted to be active in endoplasmic reticulum and extracellular space. Is expressed in several structures, including axis; brain; hatching gland; pleuroperitoneal region; and sensory system. Human ortholog(s) of this gene implicated in Parkinsonism; breast cancer; carcinoma (multiple); and pancreatic cancer. Orthologous to human MANF (mesencephalic astrocyte derived neurotrophic factor).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 13 figures from 6 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:6909481 (15 images)
Wild Type Expression Summary
- All Phenotype Data
- 3 figures from Chen et al., 2012
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Diabetes, deafness, developmental delay, and short stature syndrome | 620651 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | ARMET, C-terminal | ARMET-like | ARMET, N-terminal | SAP domain superfamily |
|---|---|---|---|---|---|---|
| UniProtKB:Q08CA7 | InterPro | 180 |
- Genome Browsers
Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-manf | polyclonal | IgG | Rabbit |
|
ProSci Incorporated
|
2 |
Plasmids
No data available
- Genome Browsers