scn1lab

ID

ZDB-GENE-060906-1

Name

sodium channel, voltage-gated, type I like, alpha b

Symbol

scn1lab Nomenclature History

Previous Names

zscn2 (1)
did
didy

Type

protein_coding_gene

Location

Chr: 6 Mapping Details/Browsers

Genome Assembly

GRCz12tu

Annotation Status

Current

Description

Predicted to enable voltage-gated sodium channel activity. Acts upstream of or within several processes, including neuronal action potential; regulation of generation of precursor metabolites and energy; and swimming behavior. Predicted to be located in plasma membrane. Predicted to be part of voltage-gated sodium channel complex. Predicted to be active in axon. Is expressed in heart and nervous system. Used to study Dravet syndrome; anxiety disorder; and epilepsy. Human ortholog(s) of this gene implicated in epilepsy (multiple); episodic ataxia type 9; erythromelalgia; familial hemiplegic migraine 3; and paroxysmal extreme pain disorder. Orthologous to several human genes including SCN3A (sodium voltage-gated channel alpha subunit 3).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

9 figures from 9 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 50 figures from 17 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With scn1lab Human Ortholog

No data available

Associated With scn1lab Via Experimental Models

Human Disease	Fish	Conditions	Citations
anxiety disorder	scn1lab^s552/s552	standard conditions	Grone et al., 2017
epilepsy	scn1lab^s552/s552	standard conditions	(2)
epilepsy	scn1lab^s552/s552	standard conditions	Hong et al., 2016
Dravet syndrome	WT + MO2-scn1lab	standard conditions	Brenet et al., 2019
Dravet syndrome	scn1lab^s552/s552; ot1Tg	standard conditions	Grone et al., 2017
Dravet syndrome	scn1lab^s552/s552	standard conditions	(3)
Dravet syndrome	scn1lab^zu1/zu1	standard conditions	Weuring et al., 2020
Dravet syndrome	scn1lab^{uio202/uio202} (AB)	standard conditions	Tiraboschi et al., 2020
Dravet syndrome	scn1lab^s552/s552 (TL)	control	(5)
Dravet syndrome	scn1lab^s552/s552	standard conditions	(2)

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR005821	Ion transport domain
Domain	IPR010526	Sodium ion transport-associated domain
Domain	IPR024583	Voltage-gated Na+ ion channel, cytoplasmic domain
Domain	IPR044564	Voltage-gated sodium channel alpha subunit, inactivation gate
Family	IPR001696	Voltage gated sodium channel, alpha subunit
Family	IPR043203	Voltage-gated cation channel calcium and sodium
Homologous_superfamily	IPR027359	Voltage-dependent channel domain superfamily