Gene
lhx4
- ID
- ZDB-GENE-060728-1
- Name
- LIM homeobox 4
- Symbol
- lhx4 Nomenclature History
- Previous Names
-
- si:dkeyp-35f11.3
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Acts upstream of or within pituitary gland development and ventral spinal cord interneuron specification. Predicted to be active in nucleus. Is expressed in adenohypophyseal placode; nervous system; spinal cord neural keel; and spinal cord neural tube. Used to study combined pituitary hormone deficiency. Human ortholog(s) of this gene implicated in combined pituitary hormone deficiency 4. Orthologous to human LHX4 (LIM homeobox 4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 7 figures from Roisman-Geller et al., 2024
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| combined pituitary hormone deficiency 4 | Alliance | Pituitary hormone deficiency, combined, 4 | 262700 |
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| combined pituitary hormone deficiency | lhx4tlv12/tlv12 | standard conditions | Roisman-Geller et al., 2024 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR017970 | Homeobox, conserved site |
| Domain | IPR001356 | Homeodomain |
| Domain | IPR001781 | Zinc finger, LIM-type |
| Domain | IPR047956 | LIM/homeobox protein Lhx4, LIM domain 1 |
| Domain | IPR049594 | LIM/homeobox protein Lhx3/4-like, LIM domain 2 |
| Family | IPR050453 | LIM/homeobox transcription factors |
| Homologous_superfamily | IPR009057 | Homedomain-like superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Homedomain-like superfamily | Homeobox, conserved site | Homeodomain | LIM/homeobox protein Lhx3/4-like, LIM domain 2 | LIM/homeobox protein Lhx4, LIM domain 1 | LIM/homeobox transcription factors | Zinc finger, LIM-type |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:B0S5S7 | InterPro | 391 | |||||||
| UniProtKB:A0A8M9PR07 | InterPro | 270 |
Interactions and Pathways
No data available
Plasmids
No data available