Gene
bms1
- ID
- ZDB-GENE-060720-2
- Name
- BMS1 ribosome biogenesis factor
- Symbol
- bms1 Nomenclature History
- Previous Names
-
- bms1l
- im:7152071
- wu:fb37d08
- Type
- protein_coding_gene
- Location
- Chr: 12 Mapping Details/Browsers
- Description
- Predicted to enable GTP binding activity; GTPase activity; and U3 snoRNA binding activity. Acts upstream of or within liver development; pancreas development; and rRNA processing. Located in nucleolus. Is expressed in gut; liver; pancreas; and retina. Human ortholog(s) of this gene implicated in nonsyndromic aplasia cutis congenita. Orthologous to human BMS1 (BMS1 ribosome biogenesis factor).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7152071 (1 image)
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa9116 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa27975 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa35313 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sq163 | Allele with one point mutation | Unknown | Missense | ENU | |
| zju24 | Allele with one delins | Exon 2 | Unknown | CRISPR |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-bms1 | (2) | |
| MO1-bms1 | N/A | Wang et al., 2012 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| nonsyndromic aplasia cutis congenita | Alliance | ?Aplasia cutis congenita, nonsyndromic | 107600 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | AARP2CN | Bms1/Tsr1-type G domain | P-loop containing nucleoside triphosphate hydrolase | Ribosome biogenesis protein Bms1, N-terminal | Ribosome biogenesis protein Bms1/Tsr1 | Ribosome biogenesis protein BMS1/TSR1, C-terminal |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:E7F349 | InterPro | 1221 |
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- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-214E3 | ZFIN Curated Data | |
| Contains | SNP | rs3728496 | ZFIN Curated Data | |
| Encodes | EST | fb37d08 | ||
| Encodes | EST | IMAGE:7152071 | Thisse et al., 2004 | |
| Encodes | cDNA | MGC:174737 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001111150 (1) | 5298 nt | ||
| Genomic | GenBank:BX248124 (1) | 211571 nt | ||
| Polypeptide | UniProtKB:E7F349 (1) | 1221 aa |
- Wang, Y., Zhao, Z., Yu, H., Shi, H., Tao, B., He, Y., Chen, J., Peng, J., Gan, M., Lo, L.J. (2023) Stability and function of RCL1 are dependent on interaction with BMS1. Journal of molecular cell biology. 15(7):
- Doretto, L.B., Butzge, A.J., Nakajima, R.T., Martinez, E.R.M., de Souza, B.M., Rodrigues, M.D.S., Rosa, I.F., Ricci, J.M.B., Tovo-Neto, A., Costa, D.F., Malafaia, G., Shao, C., Nóbrega, R.H. (2022) Gdnf Acts as a Germ Cell-Derived Growth Factor and Regulates the Zebrafish Germ Stem Cell Niche in Autocrine- and Paracrine-Dependent Manners. Cells. 11(8):
- Zhu, Y., Wang, Y., Tao, B., Han, J., Chen, H., Zhu, Q., Huang, L., He, Y., Hong, J., Li, Y., Chen, J., Huang, J., Lo, L.J., Peng, J. (2021) Nucleolar GTPase Bms1 displaces Ttf1 from RFB-sites to balance progression of rDNA transcription and replication. Journal of molecular cell biology. 13(12):902-917
- Tao, B., Lo, L.J., Peng, J., He, J. (2020) rDNA subtypes and their transcriptional expression in zebrafish at different developmental stages. Biochemical and Biophysical Research Communications. 529(3):819-825
- Wang, Y., Zhu, Q., Huang, L., Zhu, Y., Chen, J., Peng, J., Lo, L.J. (2016) Interaction between Bms1 and Rcl1, two ribosome biogenesis factors, is evolutionally conserved in zebrafish and human. Journal of genetics and genomics = Yi chuan xue bao. 43(7):467-9
- Guan, Y., Zhu, Q., Huang, D., Zhao, S., Jan Lo, L., Peng, J. (2015) An equation to estimate the difference between theoretically predicted and SDS PAGE-displayed molecular weights for an acidic peptide. Scientific Reports. 5:13370
- Azuaje, F.J. (2014) Selecting biologically informative genes in co-expression networks with a centrality score. Biology Direct. 9:12
- Wang, Y., Luo, Y., Hong, Y., Peng, J., and Lo, L. (2012) Ribosome Biogenesis Factor Bms1-like Is Essential for Liver Development in Zebrafish. Journal of genetics and genomics = Yi chuan xue bao. 39(9):451-462
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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