Gene

thrab

ID
ZDB-GENE-060613-1
Name
thyroid hormone receptor alpha b
Symbol
thrab Nomenclature History
Previous Names
  • c-erbA (1)
  • NR1A1-B (1)
  • nr1a1b (1)
Type
protein_coding_gene
Location
Chr: 12 Mapping Details/Browsers
Description
Predicted to have several functions, including DNA-binding transcription factor activity; RNA polymerase II regulatory region sequence-specific DNA binding activity; and nuclear receptor transcription coactivator activity. Predicted to be involved in several processes, including animal organ development; regulation of transcription by RNA polymerase II; and thyroid hormone mediated signaling pathway. Predicted to localize to RNA polymerase II transcription factor complex. Human ortholog(s) of this gene implicated in congenital nongoitrous hypothyroidism 6 and renal cell carcinoma. Is expressed in several structures, including blastodisc; cardiovascular system; mandibular arch skeleton; nervous system; and pleuroperitoneal region. Orthologous to human THRA (thyroid hormone receptor alpha).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
17 figures from 9 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
11 figures from 2 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With thrab Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
congenital nongoitrous hypothyroidism 6 Alliance Hypothyroidism, congenital, nongoitrous, 6 614450
Associated With thrab Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000536 Nuclear hormone receptor, ligand-binding domain
Domain IPR001628 Zinc finger, nuclear hormone receptor-type
Family IPR001723 Nuclear hormone receptor
Family IPR001728 Thyroid hormone receptor
Family IPR003078 Retinoic acid receptor
Homologous_superfamily IPR013088 Zinc finger, NHR/GATA-type
Homologous_superfamily IPR035500 Nuclear hormone receptor-like domain superfamily
Domain Details Per Protein
Protein Length Nuclear hormone receptor Nuclear hormone receptor, ligand-binding domain Nuclear hormone receptor-like domain superfamily Retinoic acid receptor Thyroid hormone receptor Zinc finger, NHR/GATA-type Zinc finger, nuclear hormone receptor-type
UniProtKB:A0ST48 190
UniProtKB:A0A286Y807 403
UniProtKB:Q1L674 316
UniProtKB:U3JAT9 409
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations