Gene
pals1b
- ID
- ZDB-GENE-060531-2
- Name
- protein associated with LIN7 1, MAGUK p55 family member b
- Symbol
- pals1b Nomenclature History
- Previous Names
-
- im:7140055
- mpp5b
- ponli (1)
- sb:eu974
- si:ch211-105d18.1
- Type
- protein_coding_gene
- Location
- Chr: 20 Mapping Details/Browsers
- Description
- Predicted to be involved in several processes, including establishment or maintenance of epithelial cell apical/basal polarity; morphogenesis of an epithelium; and protein localization to plasma membrane. Predicted to be located in apical plasma membrane and bicellular tight junction. Predicted to be active in adherens junction and plasma membrane. Is expressed in eye; retinal cone cell; and retinal photoreceptor layer. Orthologous to human PALS1 (protein associated with LIN7 1, MAGUK p55 family member).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la021726Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la021727Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| zju204 | Allele with one deletion | Exon 2 | Unknown | CRISPR |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-pals1b | Zebrafish Nomenclature Committee | |
| MO1-pals1b | N/A | (3) |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Guanylate kinase, conserved site | Guanylate kinase-like domain | Guanylate kinase/L-type calcium channel beta subunit | L27 domain | L27 domain, C-terminal | L27 domain superfamily | L27-N | Membrane-associated guanylate kinase | MPP5, SH3 domain | PDZ domain | PDZ superfamily | P-loop containing nucleoside triphosphate hydrolase | SH3 domain | SH3-like domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:D3X469 | InterPro | 639 | ||||||||||||||
| UniProtKB:A8DZ97 | InterPro | 363 | ||||||||||||||
| UniProtKB:A0A8M3B4D4 | InterPro | 512 | ||||||||||||||
| UniProtKB:A0A8M9PP48 | InterPro | 403 | ||||||||||||||
| UniProtKB:A0A8M3AL41 | InterPro | 537 |
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Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-pals1b | polyclonal | Rabbit |
|
3 |
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Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(-1.9pals1b:pals1b-GFP) |
|
|
| 4 | Fang et al., 2017 |
| Tg(-6.1pals1b:pals1b-HA-mCherry) |
|
| 1 | Fang et al., 2017 | |
| Tg(gnat2:pals1b-GFP) |
|
| 1 | Hu et al., 2025 |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-105D18 | ZFIN Curated Data | |
| Encodes | EST | eu974 | Thisse et al., 2005 | |
| Encodes | EST | IMAGE:7140055 | Thisse et al., 2004 | |
| interacts with | Enhancer | en.mpp5b_enh1 | Fang et al., 2017 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001423432 (1) | 4254 nt | ||
| Genomic | GenBank:AL928824 (1) | 189742 nt | ||
| Polypeptide | UniProtKB:A0A8M1NWX5 (1) | 639 aa |
- Hu, D., Masai, I. (2025) Dscamb regulates cone mosaic formation in zebrafish via filopodium-mediated homotypic recognition. Nature communications. 16:25012501
- Hao, Y., Zhou, Y., Yu, Y., Zheng, M., Weng, K., Kou, Z., Liang, J., Zhang, Q., Tang, X., Xu, P., Link, B.A., Yao, K., Zou, J. (2020) Interplay of MPP5a with Rab11 synergistically builds epithelial apical polarity and zonula adherens. Development (Cambridge, England). 147(22):
- Fang, W., Guo, C., Wei, X. (2017) Rainbow Enhancers Regulate Restrictive Transcription in Teleost Green, Red, and Blue Cones.. The Journal of neuroscience : the official journal of the Society for Neuroscience. 37(11):2834-2848
- Braasch, I., Gehrke, A.R., Smith, J.J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A.M., Campbell, M.S., Barrell, D., Martin, K.J., Mulley, J.F., Ravi, V., Lee, A.P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F.E., Sun, Y., Hertel, J., Beam, M.J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J.H., Litman, G.W., Litman, R.T., Mikami, M., Ota, T., Saha, N.R., Williams, L., Stadler, P.F., Wang, H., Taylor, J.S., Fontenot, Q., Ferrara, A., Searle, S.M., Aken, B., Yandell, M., Schneider, I., Yoder, J.A., Volff, J.N., Meyer, A., Amemiya, C.T., Venkatesh, B., Holland, P.W., Guiguen, Y., Bobe, J., Shubin, N.H., Di Palma, F., Alföldi, J., Lindblad-Toh, K., Postlethwait, J.H. (2016) The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nature Genetics. 48(4):427-37
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Zou, J., Wen, Y., Yang, X., and Wei, X. (2013) Spatial-temporal expressions of Crumbs and Nagie oko and their interdependence in zebrafish central nervous system during early development. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. 31(8):770-782
- Zou, J., Yang, X., and Wei, X. (2010) Restricted localization of ponli, a novel zebrafish MAGUK-family protein, to the inner segment interface areas between green, red, and blue cones. Investigative ophthalmology & visual science. 51(3):1738-1746
- Yang, X., Zou, J., Hyde, D.R., Davidson, L.A., and Wei, X. (2009) Stepwise maturation of apicobasal polarity of the neuroepithelium is essential for vertebrate neurulation. The Journal of neuroscience : the official journal of the Society for Neuroscience. 29(37):11426-11440
- Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433
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