ZFIN is now using GRCz12tu for Genomic Data
Gene
acaca
- ID
- ZDB-GENE-060526-74
- Name
- acetyl-CoA carboxylase alpha
- Symbol
- acaca Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable acetyl-CoA carboxylase activity. Acts upstream of or within response to (R)-carnitine. Predicted to be located in cytoplasm. Predicted to be active in mitochondrion. Is expressed in adipose tissue; female organism; liver; and male organism. Orthologous to human ACACA (acetyl-CoA carboxylase alpha).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 42 figures from 35 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Acetyl-CoA carboxylase deficiency | 613933 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Binding_site | IPR001882 | Biotin-binding site |
| Domain | IPR000089 | Biotin/lipoyl attachment |
| Domain | IPR005481 | Biotin carboxylase-like, N-terminal domain |
| Domain | IPR005482 | Biotin carboxylase, C-terminal |
| Domain | IPR011761 | ATP-grasp fold |
| Domain | IPR011762 | Acetyl-coenzyme A carboxyltransferase, N-terminal |
| Domain | IPR011763 | Acetyl-coenzyme A carboxyltransferase, C-terminal |
| Domain | IPR011764 | Biotin carboxylation domain |
| Domain | IPR013537 | Acetyl-CoA carboxylase, central domain |
| Domain | IPR034733 | Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta |
| Domain | IPR049074 | Acetyl-CoA carboxylase, BT domain |
| Family | IPR049076 | Acetyl-CoA carboxylase |
| Homologous_superfamily | IPR011053 | Single hybrid motif |
| Homologous_superfamily | IPR011054 | Rudiment single hybrid motif |
| Homologous_superfamily | IPR013815 | ATP-grasp fold, subdomain 1 |
| Homologous_superfamily | IPR016185 | Pre-ATP-grasp domain superfamily |
| Homologous_superfamily | IPR029045 | ClpP/crotonase-like domain superfamily |
Domain Details Per Protein
- Genome Browsers
Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab4-acaca | polyclonal | Rabbit |
|
Sangon Biotech
|
2 |
Plasmids
No data available
- Genome Browsers