ZFIN is now using GRCz12tu for Genomic Data
Gene
whrnb
- ID
- ZDB-GENE-060526-377
- Name
- whirlin b
- Symbol
- whrnb Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to be involved in auditory receptor cell stereocilium organization and sensory perception of sound. Predicted to be part of stereocilia ankle link complex. Predicted to be active in cilium; plasma membrane; and stereocilium tip. Is expressed in hair cell. Human ortholog(s) of this gene implicated in Usher syndrome type 2D; autosomal recessive nonsyndromic deafness 31; and sensorineural hearing loss. Orthologous to human WHRN (whirlin).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Blanco-Sánchez et al., 2014
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal recessive nonsyndromic deafness 31 | Alliance | Deafness, autosomal recessive 31 | 607084 |
| Usher syndrome type 2D | Alliance | Usher syndrome, type 2D | 611383 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | PDZ domain | PDZ superfamily | Sensory Perception USH2 Complex Protein | Whirlin, harmonin_N-like domain 1 | Whirlin, harmonin_N-like domain 2 |
|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M9Q8S8 | InterPro | 432 | |||||
| UniProtKB:A0A8M9P8V0 | InterPro | 946 | |||||
| UniProtKB:F1R807 | InterPro | 946 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers