Gene

piwil2

ID

ZDB-GENE-060526-345

Name

piwi-like RNA-mediated gene silencing 2

Symbol

piwil2 Nomenclature History

Previous Names

zili (1)
sb:eu354
si:dkey-88f5.1

Type

protein_coding_gene

Location

Chr: 5 Mapping Details/Browsers

Description

Exhibits piRNA binding activity. Involved in several processes, including germ-line stem cell population maintenance; negative regulation of SMAD protein complex assembly; and piRNA metabolic process. Localizes to P granule and nucleus. Is expressed in axis; blastoderm; blastodisc; pharyngeal arch 3-7; and reproductive system. Orthologous to human PIWIL2 (piwi like RNA-mediated gene silencing 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

11 figures from 6 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

eu354 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 4 figures from 3 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With piwil2 Human Ortholog

No data available

Associated With piwil2 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR003100	PAZ domain
Domain	IPR003165	Piwi domain
Domain	IPR014811	Argonaute, linker 1 domain
Homologous_superfamily	IPR012337	Ribonuclease H-like superfamily
Homologous_superfamily	IPR036085	PAZ domain superfamily
Homologous_superfamily	IPR036397	Ribonuclease H superfamily

Domain Details Per Protein

Protein	Length	Argonaute, linker 1 domain	PAZ domain	PAZ domain superfamily	Piwi domain	Ribonuclease H-like superfamily	Ribonuclease H superfamily
UniProtKB:A2CEI6 InterPro	1046
UniProtKB:A0A8M9PKJ0 InterPro	1046

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	piwil2-202 (1) Ensembl	Havana	3464 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	piwil2-203 (1) Ensembl	Havana	736 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

Name	Type	Antigen Genes	Isotype	Host Organism	Assay	Source	Citations
AB2-piwil2	polyclonal	piwil2		Rabbit	IHC WB		2
Ab1-piwil2	polyclonal	piwil2		Rabbit			2

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations