ZFIN is now using GRCz12tu for Genomic Data
Gene

rac1b

ID
ZDB-GENE-060312-45
Name
Rac family small GTPase 1b
Symbol
rac1b Nomenclature History
Previous Names
  • zgc:136799
Type
protein_coding_gene
Location
Chr: 3 Mapping Details/Browsers
Genome Assembly
GRCz12tu
Annotation Status
Current
Description
Predicted to enable GTP binding activity; GTPase activity; and protein kinase binding activity. Predicted to be involved in several processes, including Rac protein signal transduction; cytoskeleton organization; and motor neuron axon guidance. Predicted to be active in several cellular components, including cytoplasmic vesicle; cytoskeleton; and plasma membrane. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 48; colorectal cancer (multiple); lung cancer; and pancreatic adenocarcinoma. Orthologous to human RAC1 (Rac family small GTPase 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
No data available
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
1 Figure from Epting et al., 2015
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
No data available
Sequence Targeting Reagents
Targeting Reagent Created Alleles Citations
MO1-rac1bN/AEpting et al., 2015
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Human Disease
Associated With rac1b Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
autosomal dominant intellectual developmental disorder 48 Alliance Intellectual developmental disorder, autosomal dominant 48 617751
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Associated With rac1b Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR005225 Small GTP-binding domain
Family IPR001806 Small GTPase
Family IPR003578 Small GTPase Rho
Homologous_superfamily IPR027417 P-loop containing nucleoside triphosphate hydrolase
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Domain Details Per Protein
Protein Additional Resources Length P-loop containing nucleoside triphosphate hydrolase Small GTPase Small GTPase Rho Small GTP-binding domain
UniProtKB:Q29RC5 InterPro 192
1 - 1 of 1
Transcripts
Genome Browsers
Genome Assembly: GRCz11Chromosome: 3
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA rac1b-201 (1) Ensembl 1,415 nt
ncRNA rac1b-002 (1) Ensembl 813 nt
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Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab2-rac1 monoclonal IgG2b Mouse
Millipore
3
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Plasmids
No data available
Constructs
No data available
Marker Relationships
Relationship Marker Type Marker Accession Numbers Citations
Contained inBACCH211-189A21ZFIN Curated Data
Contained inBACDKEY-265E17ZFIN Curated Data
EncodescDNAMGC:136799ZFIN Curated Data
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Sequences
Genome Browsers
Genome Assembly: GRCz12tuChromosome: 3
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Species Symbol Chromosome Accession # Evidence
HumanRAC17
Conserved genome location (synteny) (1)
Amino acid sequence comparison (1)
MouseRac15
Amino acid sequence comparison (1)
Conserved genome location (synteny) (1)
Citations
1 - 10 of 13
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