ZFIN is now using GRCz12tu for Genomic Data
Gene

ush1c

ID
ZDB-GENE-060312-41
Name
Usher syndrome 1C
Symbol
ush1c Nomenclature History
Previous Names
  • harmonin
  • zgc:136806
Type
protein_coding_gene
Location
Chr: 25 Mapping Details/Browsers
Genome Assembly
GRCz12tu
Annotation Status
Current
Description
Predicted to be involved in neuron development and sensory perception of sound. Predicted to be part of stereocilia ankle link complex. Predicted to be active in several cellular components, including cilium; photoreceptor inner segment; and stereocilium tip. Is expressed in brain; hair cell; pleuroperitoneal region; sensory system; and trunk musculature. Used to study Usher syndrome. Human ortholog(s) of this gene implicated in Usher syndrome; Usher syndrome type 1; Usher syndrome type 1C; and autosomal recessive nonsyndromic deafness 18A. Orthologous to human USH1C (USH1 protein network component harmonin).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
9 figures from 3 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
7 figures from 3 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With ush1c Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
autosomal recessive nonsyndromic deafness 18A Alliance Deafness, autosomal recessive 18A 602092
Usher syndrome type 1C Alliance Usher syndrome, type 1C 276904
Associated With ush1c Via Experimental Models
Human Disease Fish Conditions Citations
Usher syndrome AB + MO1-ush1c standard conditions Phillips et al., 2011
Usher syndrome WT + MO1-ush1c standard conditions Phillips et al., 2011
Usher syndrome ush1cfh293/fh293 standard conditions Phillips et al., 2011
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR001478 PDZ domain
Domain IPR030237 Harmonin, N-terminal
Family IPR051844 Sensory Perception USH2 Complex Protein
Homologous_superfamily IPR036034 PDZ superfamily
Domain Details Per Protein
Protein Additional Resources Length Harmonin, N-terminal PDZ domain PDZ superfamily Sensory Perception USH2 Complex Protein
UniProtKB:A0A8M3AZQ5 InterPro 586
UniProtKB:Q29RC0 InterPro 548
UniProtKB:A0AB32TJ22 InterPro 973
UniProtKB:A0AC58IVI4 InterPro 983
UniProtKB:A0AC58IVI5 InterPro 983
UniProtKB:A0AC58IVI7 InterPro 977
UniProtKB:A0AC58IVI9 InterPro 945
UniProtKB:A0AC58IVJ0 InterPro 977
UniProtKB:A0AC58IVJ1 InterPro 967
UniProtKB:A0AC58IVJ2 InterPro 558
UniProtKB:A0AC58IVJ3 InterPro 967
UniProtKB:A0AC58IVJ4 InterPro 939
UniProtKB:A0AC58IVJ6 InterPro 973
UniProtKB:A0AC58IVJ8 InterPro 586
UniProtKB:A0AC58IVJ9 InterPro 929
UniProtKB:A0AC58IVK2 InterPro 935
Transcripts
Genome Browsers
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA ush1c-201 (1)
Ensembl
Ensembl 1,915 nt
ZFIN BLAST
mRNA ush1c-202 (1)
Ensembl
Ensembl 975 nt
ZFIN BLAST
mRNA ush1c-203 (1)
Ensembl
Ensembl 977 nt
ZFIN BLAST
mRNA ush1c-204 (1)
Ensembl
Ensembl 1,699 nt
ZFIN BLAST
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-ush1c polyclonal Rabbit
  • IHC
 1
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Genome Browsers
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations
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