Gene
atp5fa1
- ID
- ZDB-GENE-060201-1
- Name
- ATP synthase F1 subunit alpha
- Symbol
- atp5fa1 Nomenclature History
- Previous Names
-
- atp5a1
- zgc:154103
- Type
- protein_coding_gene
- Location
- Chr: 21 Mapping Details/Browsers
- Description
- Enables lipoteichoic acid binding activity. Acts upstream of or within with a positive effect on defense response to bacterium. Predicted to be located in membrane. Predicted to be part of proton-transporting ATP synthase complex. Is expressed in several structures, including digestive system; fin; muscle; nervous system; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 22; mitochondrial complex V (ATP synthase) deficiency nuclear type 4A; and mitochondrial complex V (ATP synthase) deficiency nuclear type 4B. Orthologous to human ATP5F1A (ATP synthase F1 subunit alpha).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 8 figures from 6 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| combined oxidative phosphorylation deficiency 22 | Alliance | ?Combined oxidative phosphorylation deficiency 22 | 616045 |
| mitochondrial complex V (ATP synthase) deficiency nuclear type 4A | Alliance | Mitochondrial complex V (ATP synthase) deficiency, nuclear type 4A | 620358 |
| mitochondrial complex V (ATP synthase) deficiency nuclear type 4B | Alliance | ?Mitochondrial complex V (ATP synthase) deficiency, nuclear type 4B, encephalopathic type | 615228 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR020003 | ATPase, alpha/beta subunit, nucleotide-binding domain, active site |
| Domain | IPR000194 | ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding domain |
| Domain | IPR000793 | ATP synthase, alpha subunit, C-terminal |
| Domain | IPR004100 | ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal domain |
| Domain | IPR033732 | ATP synthase, F1 complex, alpha subunit nucleotide-binding domain |
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Domain Details Per Protein
| Protein | Additional Resources | Length | ATPase, alpha/beta subunit, nucleotide-binding domain, active site | ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal domain | ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal domain superfamily | ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding domain | ATP synthase, alpha subunit, C-terminal | ATP synthase, alpha subunit, C-terminal domain superfamily | ATP synthase, F1 complex, alpha subunit | ATP synthase, F1 complex, alpha subunit nucleotide-binding domain | ATP synthase subunit alpha, N-terminal domain-like superfamily | P-loop containing nucleoside triphosphate hydrolase |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q08BA1 | InterPro | 551 |
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- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
atp5fa1-201
(1)
|
Ensembl | 1,883 nt | ||
| ncRNA |
atp5a1-002
(1)
|
Ensembl | 440 nt |
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Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-atp5a1 | monoclonal | IgG2b , k | Mouse |
|
MitoSciences
|
3 |
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Plasmids
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-314K14 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:154103 | ZFIN Curated Data | |
| Has Artifact | cDNA | MGC:56505 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001077355 (1) | 1876 nt | ||
| Genomic | GenBank:CU466288 (2) | 93071 nt | ||
| Polypeptide | UniProtKB:Q08BA1 (1) | 551 aa |
- She, P., Gao, B., Li, D., Wu, C., Zhu, X., He, Y., Mo, F., Qi, Y., Jin, D., Chen, Y., Zhao, X., Lin, J., Hu, H., Li, J., Zhang, B., Xie, P., Lin, C., Christoffels, V.M., Wu, Y., Zhu, P., Zhong, T.P. (2025) The transcriptional repressor HEY2 regulates mitochondrial oxidative respiration to maintain cardiac homeostasis. Nature communications. 16:232232
- Le Mentec, H., Monniez, E., Legrand, A., Monvoisin, C., Lagadic-Gossmann, D., Podechard, N. (2023) A New In Vivo Zebrafish Bioassay Evaluating Liver Steatosis Identifies DDE as a Steatogenic Endocrine Disruptor, Partly through SCD1 Regulation. International Journal of Molecular Sciences. 24(4):
- Jamieson-Lucy, A.H., Kobayashi, M., James Aykit, Y., Elkouby, Y., Escobar-Aguirre, M., Vejnar, C., Giraldez, A., Mullins, M.C. (2022) A proteomics approach identifies novel resident zebrafish Balbiani body proteins Cirbpa and Cirbpb. Developmental Biology. 484:1-11
- Uszczynska-Ratajczak, B., Sugunan, S., Kwiatkowska, M., Migdal, M., Carbonell-Sala, S., Sokol, A., Winata, C.L., Chacinska, A. (2022) Profiling subcellular localization of nuclear-encoded mitochondrial gene products in zebrafish. Life science alliance. 6(1):
- Lee, J.Y., Park, H., Lim, W., Song, G. (2021) Aclonifen causes developmental abnormalities in zebrafish embryos through mitochondrial dysfunction and oxidative stress. The Science of the total environment. 771:145445
- Park, K.H., Gooz, M., Ye, Z.W., Zhang, J., Beeson, G.C., Rockey, D.C., Kim, S.H. (2021) Flavin Adenine Dinucleotide Depletion Caused by electron transfer flavoprotein subunit alpha Haploinsufficiency Leads to Hepatic Steatosis and Injury in Zebrafish. Hepatology communications. 5:976-991
- Sengupta, A., Padhan, D.K., Ganguly, A., Sen, M. (2021) Ccn6 Is Required for Mitochondrial Integrity and Skeletal Muscle Function in Zebrafish. Frontiers in cell and developmental biology. 9:627409
- Tao, Y., Yang, Y., Jiao, Y., Wu, S., Zhu, G., Akindolie, M.S., Zhu, T., Qu, J., Wang, L., Zhang, Y. (2020) Monobutyl phthalate (MBP) induces energy metabolism disturbances in the gills of adult zebrafish (Danio rerio). Environmental pollution (Barking, Essex : 1987). 266:115288
- Yang, Y., Dong, F., Liu, X., Xu, J., Wu, X., Zheng, Y. (2020) Thifluzamide induces the toxic effects on zebrafish (Danio rerio) via inhibition of succinate dehydrogenase (SDH). Environmental pollution (Barking, Essex : 1987). 265:115031
- Zhuang, J., Pan, Z.J., Mengqiu-Li, ., Hong, F.S., Zhu, C.K., Wu, N., Chang, G., Wang, H., Zhao, X.X. (2020) BDE-47 induced apoptosis in zebrafish embryos through mitochondrial ROS-mediated JNK signaling. Chemosphere. 258:127385
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