Gene

il10

ID
ZDB-GENE-051111-1
Name
interleukin 10
Symbol
il10 Nomenclature History
Previous Names
  • zgc:194510
  • zgc:194518
Type
protein_coding_gene
Location
Chr: 11 Mapping Details/Browsers
Description
Is predicted to enable cytokine activity. Acts upstream of or within defense response to bacterium and response to lipopolysaccharide. Predicted to be located in extracellular space. Is expressed in blood; digestive system; gill; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autoimmune disease (multiple); eye disease (multiple); gastrointestinal system cancer (multiple); and hematologic cancer (multiple). Orthologous to human IL10 (interleukin 10).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
52 figures from 39 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
1 Figure from Bottiglione et al., 2020
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With il10 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
rheumatoid arthritis Alliance {Rheumatoid arthritis, progression of} 180300
{Graft-versus-host disease, protection against} 614395
{HIV-1, susceptibility to} 609423
Associated With il10 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Family IPR000098 Interleukin-10
Family IPR020443 Interleukin-10/19/20/22/24/26 family
Homologous_superfamily IPR009079 Four-helical cytokine-like, core
Domain Details Per Protein
Protein Length Four-helical cytokine-like, core Interleukin-10 Interleukin-10/19/20/22/24/26 family
UniProtKB:Q5EFQ8 180
Transcripts
Genome Browsers
Interactions and Pathways
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations