graft-versus-host disease

Term ID

DOID:0081267

Synonyms

• graft versus host disease
• GvHD

Definition

An immune system disease that is characterized by recognition by mature donor T cells, that contaminate the allogeneic bone marrow, of the recipient's tissue as foreign, causing a severe inflammatory disease characterized by rashes, diarrhea, and liver disease, and that has_material_basis_in an associated with variation in the interleukin-10 gene (IL10) on chromosome 1q32. (2)

References

• ICD11:4B24
• MESH:D006086
• OMIM:614395
• ORDO:39812

Ontology

Human Disease   ( DOID:0081267 )