Gene

il10rb

ID
ZDB-GENE-050909-1
Name
interleukin 10 receptor, beta
Symbol
il10rb Nomenclature History
Previous Names
  • IL10R2 (1)
  • il10rbl
  • crfb5
  • zgc:153823
Type
protein_coding_gene
Location
Chr: 9 Mapping Details/Browsers
Description
Exhibits interferon receptor activity. Predicted to be involved in cytokine-mediated signaling pathway. Predicted to localize to integral component of membrane and plasma membrane. Human ortholog(s) of this gene implicated in hepatitis B; hepatitis C; and inflammatory bowel disease 25. Is expressed in head and heart. Orthologous to several human genes including IFNAR1 (interferon alpha and beta receptor subunit 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
1 figure from Levraud et al., 2007
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
1 Figure from Phenotype Annotation (1994-2006)
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With il10rb Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
inflammatory bowel disease 25 Alliance Inflammatory bowel disease 25, early onset, autosomal recessive 612567
{Hepatitis B virus, susceptibility to} 610424
Associated With il10rb Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR003961 Fibronectin type III
Domain IPR015373 Interferon/interleukin receptor domain
Homologous_superfamily IPR013783 Immunoglobulin-like fold
Homologous_superfamily IPR036116 Fibronectin type III superfamily
Domain Details Per Protein
Protein Length Fibronectin type III Fibronectin type III superfamily Immunoglobulin-like fold Interferon/interleukin receptor domain
UniProtKB:B8JMJ8 176
UniProtKB:A5PF68 368
UniProtKB:F1QA77 367
UniProtKB:Q3HSD4 368
UniProtKB:A0AUQ9 366
UniProtKB:A0FJI0 368
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations