ZFIN is now using GRCz12tu for Genomic Data
Gene
igsf21a
- ID
- ZDB-GENE-050809-118
- Name
- immunoglobin superfamily, member 21a
- Symbol
- igsf21a Nomenclature History
- Previous Names
-
- zgc:112341
- Type
- protein_coding_gene
- Location
- Chr: 11 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to be involved in trans-synaptic signaling, modulating synaptic transmission. Predicted to be located in membrane. Predicted to be active in postsynaptic density membrane and presynaptic membrane. Is expressed in brain; pectoral fin musculature; and retina. Orthologous to human IGSF21 (immunoglobin superfamily member 21).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 8 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cssl:d0751 (11 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la017828Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la027263Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa13436 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa21932 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa30948 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa41858 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa41859 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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No data available
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR003006 | Immunoglobulin/major histocompatibility complex, conserved site |
| Domain | IPR003599 | Immunoglobulin domain subtype |
| Domain | IPR007110 | Immunoglobulin-like domain |
| Domain | IPR013106 | Immunoglobulin V-set domain |
| Family | IPR051427 | Nectin and Nectin-like |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Immunoglobulin domain subtype | Immunoglobulin-like domain | Immunoglobulin-like domain superfamily | Immunoglobulin-like fold | Immunoglobulin/major histocompatibility complex, conserved site | Immunoglobulin V-set domain | Nectin and Nectin-like |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M1N7V4 | InterPro | 475 | |||||||
| UniProtKB:Q498W1 | InterPro | 472 | |||||||
| UniProtKB:F1QR24 | InterPro | 470 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
igsf21a-201
(1)
|
Ensembl | 3,198 nt | ||
| mRNA |
igsf21a-202
(1)
|
Ensembl | 2,235 nt | ||
| mRNA |
igsf21a-203
(1)
|
Ensembl | 836 nt |
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Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-igsf21a | monoclonal | Mouse |
|
1 |
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Plasmids
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-253N14 | ZFIN Curated Data | |
| Contained in | BAC | CH211-22E19 | ZFIN Curated Data | |
| Contained in | BAC | CH211-226M7 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-104I23 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-238D19 | ZFIN Curated Data | |
| Contained in | Fosmid | CH1073-508K1 | ZFIN Curated Data | |
| Encodes | EST | cssl:d0751 | Thisse et al., 2008 | |
| Encodes | cDNA | MGC:112341 | ZFIN Curated Data |
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| Type | Accession # | Genome Assembly | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001034184 (1) | 2250 nt | ||
| Genomic | GenBank:BX470199 (1) | 197146 nt | ||
| Polypeptide | UniProtKB:A0A8M1N7V4 (1) | 475 aa |
- Riesle, A.J., Gao, M., Rosenblatt, M., Hermes, J., Hass, H., Gebhard, A., Veil, M., Grüning, B., Timmer, J., Onichtchouk, D. (2023) Activator-blocker model of transcriptional regulation by pioneer-like factors. Nature communications. 14:56775677
- Gao, M., Veil, M., Rosenblatt, M., Riesle, A.J., Gebhard, A., Hass, H., Buryanova, L., Yampolsky, L.Y., Grüning, B., Ulianov, S.V., Timmer, J., Onichtchouk, D. (2022) Pluripotency factors determine gene expression repertoire at zygotic genome activation. Nature communications. 13:788
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Thomas-Jinu, S., Gordon, P.M., Fielding, T., Taylor, R., Smith, B.N., Snowden, V., Blanc, E., Vance, C., Topp, S., Wong, C.H., Bielen, H., Williams, K.L., McCann, E.P., Nicholson, G.A., Pan-Vazquez, A., Fox, A.H., Bond, C.S., Talbot, W.S., Blair, I.P., Shaw, C.E., Houart, C. (2017) Non-nuclear Pool of Splicing Factor SFPQ Regulates Axonal Transcripts Required for Normal Motor Development. Neuron. 94(2):322-336.e5
- Braasch, I., Gehrke, A.R., Smith, J.J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A.M., Campbell, M.S., Barrell, D., Martin, K.J., Mulley, J.F., Ravi, V., Lee, A.P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F.E., Sun, Y., Hertel, J., Beam, M.J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J.H., Litman, G.W., Litman, R.T., Mikami, M., Ota, T., Saha, N.R., Williams, L., Stadler, P.F., Wang, H., Taylor, J.S., Fontenot, Q., Ferrara, A., Searle, S.M., Aken, B., Yandell, M., Schneider, I., Yoder, J.A., Volff, J.N., Meyer, A., Amemiya, C.T., Venkatesh, B., Holland, P.W., Guiguen, Y., Bobe, J., Shubin, N.H., Di Palma, F., Alföldi, J., Lindblad-Toh, K., Postlethwait, J.H. (2016) The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nature Genetics. 48(4):427-37
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Liu, J., Merkle, F.T., Gandhi, A.V., Gagnon, J.A., Woods, I.G., Chiu, C.N., Shimogori, T., Schier, A.F., Prober, D.A. (2015) Evolutionarily conserved regulation of hypocretin neuron specification by Lhx9. Development (Cambridge, England). 142(6):1113-24
- Staudt, N., Müller-Sienerth, N., Fane-Dremucheva, A., Yusaf, S.P., Millrine, D., Wright, G.J. (2015) A panel of recombinant monoclonal antibodies against zebrafish neural receptors and secreted proteins suitable for wholemount immunostaining. Biochemical and Biophysical Research Communications. 456(1):527-33
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433
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