Gene

vps11

ID
ZDB-GENE-050731-5
Name
VPS11 core subunit of CORVET and HOPS complexes
Symbol
vps11 Nomenclature History
Previous Names
  • unm_w66 (1)
  • zgc:112329 (1)
Type
protein_coding_gene
Location
Chr: 10 Mapping Details/Browsers
Description
Predicted to have protein-macromolecule adaptor activity. Involved in several processes, including animal organ development; melanocyte apoptotic process; and melanocyte differentiation. Predicted to localize to HOPS complex and endosome. Is expressed in brain; heart; immature eye; and retina. Human ortholog(s) of this gene implicated in hypomyelinating leukodystrophy 12. Orthologous to human VPS11 (VPS11 core subunit of CORVET and HOPS complexes).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
3 figures from 3 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
15 figures from 4 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With vps11 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
hypomyelinating leukodystrophy 12 Alliance Leukodystrophy, hypomyelinating, 12 616683
?Dystonia 32 619637
Associated With vps11 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR001841 Zinc finger, RING-type
Domain IPR024763 Vacuolar protein sorting protein 11, C-terminal
Family IPR016528 Vacuolar protein sorting-associated protein 11
Homologous_superfamily IPR011990 Tetratricopeptide-like helical domain superfamily
Homologous_superfamily IPR013083 Zinc finger, RING/FYVE/PHD-type
Homologous_superfamily IPR015943 WD40/YVTN repeat-like-containing domain superfamily
Homologous_superfamily IPR016024 Armadillo-type fold
Homologous_superfamily IPR036322 WD40-repeat-containing domain superfamily
Repeat IPR000547 Clathrin, heavy chain/VPS, 7-fold repeat
Domain Details Per Protein
Protein Length Armadillo-type fold Clathrin, heavy chain/VPS, 7-fold repeat Tetratricopeptide-like helical domain superfamily Vacuolar protein sorting-associated protein 11 Vacuolar protein sorting protein 11, C-terminal WD40-repeat-containing domain superfamily WD40/YVTN repeat-like-containing domain superfamily Zinc finger, RING/FYVE/PHD-type Zinc finger, RING-type
UniProtKB:F1QVG9 927
UniProtKB:Q4G0A0 927
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-vps11 polyclonal IgG Goat
  • WB
Abcam plc
1
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations