Gene
cspg4
- ID
- ZDB-GENE-050519-1
- Name
- chondroitin sulfate proteoglycan 4
- Symbol
- cspg4 Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 25 Mapping Details/Browsers
- Description
- Is expressed in several structures, including head mesenchyme; inner ear; mesoderm; vasculature; and ventral mesenchyme. Human ortholog(s) of this gene implicated in relapsing-remitting multiple sclerosis. Orthologous to human CSPG4 (chondroitin sulfate proteoglycan 4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 6 figures from Lee et al., 2020
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la023390Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa12954 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa14510 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa15270 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa24601 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa37999 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa39470 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| twu0405 | Allele with one insertion | Unknown | Unknown | CRISPR |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Concanavalin A-like lectin/glucanase domain superfamily | CSPG repeat | FRAS1-related extracellular matrix | Laminin G domain |
|---|---|---|---|---|---|---|
| UniProtKB:E7FCN9 | InterPro | 2305 |
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Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| TgBAC(cspg4:GAL4) |
|
| 1 | Touret et al., 2022 | |
| TgBAC(cspg4:mCherry) |
|
| 1 | (2) |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-93N11 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-105I23 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_001923422 (1) | 11705 nt | ||
| Genomic | GenBank:CR354425 (1) | 161571 nt | ||
| Polypeptide | UniProtKB:E7FCN9 (1) | 2305 aa |
- Bromley-Coolidge, S., Iruegas, D., Appel, B. (2024) Cspg4 sculpts oligodendrocyte precursor cell morphology. Differentiation; research in biological diversity. 140:100819100819
- Saraswathy, V.M., Zhou, L., Mokalled, M.H. (2024) Single-cell analysis of innate spinal cord regeneration identifies intersecting modes of neuronal repair. Nature communications. 15:68086808
- Ribeiro, A., Rebocho da Costa, M., de Sena-Tomás, C., Rodrigues, E.C., Quitéria, R., Maçarico, T., Rosa Santos, S.C., Saúde, L. (2023) Development and repair of blood vessels in the zebrafish spinal cord. Open Biology. 13:230103230103
- Zhang, T., Alonzo, I., Stubben, C., Geng, Y., Herdman, C., Chandler, N., Doane, K.P., Pluimer, B.R., Trauger, S.A., Peterson, R.T. (2023) A zebrafish model of Combined Saposin Deficiency identifies acid sphingomyelinase as a potential therapeutic target. Disease models & mechanisms. 16(7):
- Touret, A.L., Vivier, C., Schmidt, A., Herbomel, P., Murayama, E. (2022) A dual involvement of Protocadherin-18a in stromal cell development guides the formation of a functional hematopoietic niche. Development (Cambridge, England). 149(19)
- Lawson, N.D., Li, R., Shin, M., Grosse, A., Yukselen, O., Stone, O.A., Kucukural, A., Zhu, L. (2020) An improved zebrafish transcriptome annotation for sensitive and comprehensive detection of cell type-specific genes. eLIFE. 9:
- Lee, Y.H., Kawakami, K., HuangFu, W.C., Liu, I.H. (2020) Chondroitin sulfate proteoglycan 4 regulates zebrafish body axis organization via Wnt/planar cell polarity pathway. PLoS One. 15:e0230943
- Marisca, R., Hoche, T., Agirre, E., Hoodless, L.J., Barkey, W., Auer, F., Castelo-Branco, G., Czopka, T. (2020) Functionally distinct subgroups of oligodendrocyte precursor cells integrate neural activity and execute myelin formation. Nature Neuroscience. 23(3):363-374
- Scott, K., O'Rourke, R., Gillen, A., Appel, B. (2020) Prdm8 regulates pMN progenitor specification for motor neuron and oligodendrocyte fates by modulating Shh signaling response. Development (Cambridge, England). 147(16):
- Ando, K., Wang, W., Peng, D., Chiba, A., Lagendijk, A., Barske, L., Crump, J.G., Stainier, D.Y.R., Lendahl, U., Koltowska, K., Hogan, B.M., Fukuhara, S., Mochizuki, N., Betsholtz, C. (2019) Peri-arterial specification of vascular mural cells from naïve mesenchyme requires Notch signaling. Development (Cambridge, England). 146(2):
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