Gene
stk11
- ID
- ZDB-GENE-050417-383
- Name
- serine/threonine kinase 11
- Symbol
- stk11 Nomenclature History
- Previous Names
-
- lkb1 (1)
- wu:fj61a05
- zgc:110180
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Predicted to have protein serine/threonine kinase activity. Involved in several processes, including energy homeostasis; glucose homeostasis; and intestinal epithelial cell differentiation. Predicted to localize to cytoplasm and nucleus. Human ortholog(s) of this gene implicated in Peutz-Jeghers syndrome; cervical mucinous adenocarcinoma; endometrial cancer; ovarian carcinoma; and pancreatic cancer. Is expressed in digestive system; head; and trunk. Orthologous to human STK11 (serine/threonine kinase 11).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:110180 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 17 figures from 4 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| pancreatic carcinoma | Alliance | Pancreatic cancer, somatic | 260350 |
| Peutz-Jeghers syndrome | Alliance | Peutz-Jeghers syndrome | 175200 |
| testicular germ cell cancer | Alliance | Testicular tumor, somatic | 273300 |
| Melanoma, malignant, somatic | 155600 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008271 | Serine/threonine-protein kinase, active site |
| Binding_site | IPR017441 | Protein kinase, ATP binding site |
| Domain | IPR000719 | Protein kinase domain |
| Domain | IPR039154 | Serine/Threonine kinase LKB1, catalytic domain |
| Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
Domain Details Per Protein
| Protein | Length | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | Serine/Threonine kinase LKB1, catalytic domain | Serine/threonine-protein kinase, active site |
|---|---|---|---|---|---|---|
|
UniProtKB:Q568P5
|
440 |
Interactions and Pathways
No data available
Plasmids
No data available