Gene

insl3

ID
ZDB-GENE-050310-5
Name
insulin-like 3 (Leydig cell)
Symbol
insl3 Nomenclature History
Previous Names
  • rflx (1)
  • rln2
  • rlnc (1)
  • rlx3c (1)
  • si:rp71-39b20.5 (1)
Type
protein_coding_gene
Location
Chr: 2 Mapping Details/Browsers
Description
Predicted to have G protein-coupled receptor binding activity. Predicted to be involved in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway. Predicted to localize to extracellular space. Human ortholog(s) of this gene implicated in cryptorchidism. Is expressed in several structures, including endocrine system; female organism; gut; heart; and male organism. Orthologous to human INSL3 (insulin like 3).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
19 figures from 15 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
4 figures from Crespo et al., 2021
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With insl3 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
cryptorchidism Alliance Cryptorchidism 219050
Associated With insl3 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR022353 Insulin, conserved site
Domain IPR016179 Insulin-like
Family IPR022352 Insulin family
Family IPR043387 Insulin-like INSL3/INSL4
Homologous_superfamily IPR036438 Insulin-like superfamily
Domain Details Per Protein
Protein Length Insulin, conserved site Insulin family Insulin-like Insulin-like INSL3/INSL4 Insulin-like superfamily
UniProtKB:Q2P9V5 153
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations