Gene

kif7

ID

ZDB-GENE-050307-1

Name

kinesin family member 7

Symbol

kif7 Nomenclature History

Previous Names

cos2 (1)
costal2 (1)

Type

protein_coding_gene

Location

Chr: 7 Mapping Details/Browsers

Description

Predicted to have ATPase activity; microtubule binding activity; and microtubule motor activity. Involved in determination of left/right symmetry; negative regulation of smoothened signaling pathway; and photoreceptor cell outer segment organization. Localizes to Hedgehog signaling complex; cilium; and cytoplasm. Human ortholog(s) of this gene implicated in acrocallosal syndrome; cleft lip; and hydrolethalus syndrome 2. Is expressed in myotome; neural tube; otic vesicle; and somite. Orthologous to human KIF7 (kinesin family member 7).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

7 figures from 5 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 25 figures from 9 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With kif7 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
acrocallosal syndrome	Alliance	Acrocallosal syndrome	200990
acrocallosal syndrome	Alliance	Joubert syndrome 12	200990
hydrolethalus syndrome 2	Alliance	?Hydrolethalus syndrome 2	614120
		?Al-Gazali-Bakalinova syndrome	607131

Associated With kif7 Via Experimental Models

Human Disease	Fish	Conditions	Citations
idiopathic scoliosis	kif7^co63/co63 (AB)	standard conditions	(2)

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR019821	Kinesin motor domain, conserved site
Domain	IPR001752	Kinesin motor domain
Family	IPR027640	Kinesin-like protein
Homologous_superfamily	IPR027417	P-loop containing nucleoside triphosphate hydrolase
Homologous_superfamily	IPR036961	Kinesin motor domain superfamily

Domain Details Per Protein

Protein	Length	Kinesin-like protein	Kinesin motor domain	Kinesin motor domain, conserved site	Kinesin motor domain superfamily	P-loop containing nucleoside triphosphate hydrolase
UniProtKB:F1QH25 InterPro	1363
UniProtKB:Q58G59 InterPro	1363

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	kif7-201 (1) Ensembl	Havana	5802 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
ncRNA	kif7-002 (1) Ensembl	Havana	588 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

SignaFish

Antibodies

Name	Type	Antigen Genes	Isotype	Host Organism	Assay	Source	Citations
Ab1-kif7	polyclonal	kif7		Rabbit	IHC WB		1

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations