ZFIN is now using GRCz12tu for Genomic Data
Gene
wars2
- ID
- ZDB-GENE-050306-26
- Name
- tryptophanyl tRNA synthetase 2, mitochondrial
- Symbol
- wars2 Nomenclature History
- Previous Names
-
- zgc:110828 (1)
- Type
- protein_coding_gene
- Location
- Chr: 9 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable tryptophan-tRNA ligase activity. Acts upstream of or within sprouting angiogenesis. Predicted to be active in mitochondrial matrix. Human ortholog(s) of this gene implicated in mitochondrial neurodevelopmental disorder with abnormal movements and lactic acidosis, with or without seizures. Orthologous to human WARS2 (tryptophanyl tRNA synthetase 2, mitochondrial).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:6907795 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 4 figures from Wang et al., 2016
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| mitochondrial neurodevelopmental disorder with abnormal movements and lactic acidosis, with or without seizures | Alliance | Neurodevelopmental disorder, mitochondrial, with abnormal movements and lactic acidosis, with or without seizures | 617710 |
| Parkinsonism-dystonia 3, childhood-onset | 619738 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR001412 | Aminoacyl-tRNA synthetase, class I, conserved site |
| Family | IPR002305 | Aminoacyl-tRNA synthetase, class Ic |
| Family | IPR002306 | Tryptophan-tRNA ligase |
| Family | IPR024109 | Tryptophan-tRNA ligase, bacterial-type |
| Family | IPR050203 | Tryptophan--tRNA ligase |
| Homologous_superfamily | IPR014729 | Rossmann-like alpha/beta/alpha sandwich fold |
Domain Details Per Protein
| Protein | Additional Resources | Length | Aminoacyl-tRNA synthetase, class Ic | Aminoacyl-tRNA synthetase, class I, conserved site | Rossmann-like alpha/beta/alpha sandwich fold | Tryptophan--tRNA ligase | Tryptophan-tRNA ligase | Tryptophan-tRNA ligase, bacterial-type |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q5CZN2 | InterPro | 364 | ||||||
| UniProtKB:A0AB32U194 | InterPro | 290 | ||||||
| UniProtKB:A0AC58GDX5 | InterPro | 278 | ||||||
| UniProtKB:A0AC58GDX6 | InterPro | 290 | ||||||
| UniProtKB:A0AC58GDY3 | InterPro | 290 | ||||||
| UniProtKB:A0AC58GDY4 | InterPro | 409 |
- Genome Browsers
Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-wars2 | polyclonal | Rabbit |
|
Aviva Systems Biology
|
2 |
Plasmids
No data available
- Genome Browsers