ZFIN is now using GRCz12tu for Genomic Data
Gene
pcdh15b
- ID
- ZDB-GENE-050214-1
- Name
- protocadherin-related 15b
- Symbol
- pcdh15b Nomenclature History
- Previous Names
-
- im:7151077
- si:ch211-253p2.2
- Type
- protein_coding_gene
- Location
- Chr: 12 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable beta-catenin binding activity and cadherin binding activity. Predicted to be involved in cell migration and cell-cell adhesion. Predicted to be part of catenin complex. Is expressed in brain; epiphysis; eye; eye photoreceptor cell; and photoreceptor outer segment layer. Used to study Usher syndrome type 1F. Human ortholog(s) of this gene implicated in Usher syndrome type 1D; Usher syndrome type 1F; and autosomal recessive nonsyndromic deafness 23. Orthologous to human PCDH15 (protocadherin related 15).
- Genome Resources
- Note
-
pcdh15b is represented by two gene models in GRCz11
- Comparative Information
-
- All Expression Data
- 3 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 7 figures from Miles et al., 2021
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal recessive nonsyndromic deafness 23 | Alliance | Deafness, autosomal recessive 23 | 609533 |
| Usher syndrome type 1D | Alliance | Usher syndrome, type 1D/F digenic | 601067 |
| Usher syndrome type 1F | Alliance | Usher syndrome, type 1F | 602083 |
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| Usher syndrome type 1F | pcdh15buot14/uot14 | standard conditions | Miles et al., 2021 |
| Usher syndrome type 1F | pcdh15buot15/uot15 | standard conditions | Miles et al., 2021 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR020894 | Cadherin conserved site |
| Domain | IPR002126 | Cadherin-like |
| Domain | IPR041149 | Extracellular cadherin domain |
| Domain | IPR056989 | Protocadherin-15 domain |
| Family | IPR039808 | Cadherin |
| Homologous_superfamily | IPR015919 | Cadherin-like superfamily |
| Homologous_superfamily | IPR030718 | Extracellular cadherin domain superfamily |
Domain Details Per Protein
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
pcdh15b-201
(1)
|
Ensembl | 5,636 nt | ||
| mRNA |
pcdh15b-202
(1)
|
Ensembl | 324 nt | ||
| mRNA |
si:ch211-253p2.2-201
(1)
|
Ensembl | 2,794 nt |
Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-pcdh15 |
|
NSJ Bioreagents
|
2 |
Plasmids
No data available
- Genome Browsers