Gene

prkar1aa

ID
ZDB-GENE-050116-2
Name
protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1) a
Symbol
prkar1aa Nomenclature History
Previous Names
  • prkar1a
  • im:7047729
  • zgc:92515
Type
protein_coding_gene
Location
Chr: 3 Mapping Details/Browsers
Description
Predicted to have 3',5'-cyclic-GMP phosphodiesterase activity. Predicted to be involved in cGMP-mediated signaling. Predicted to localize to cytosol. Human ortholog(s) of this gene implicated in Carney complex; acrodysostosis; and primary pigmented nodular adrenocortical disease. Is expressed in early embryonic cell; immature eye; neural tube; and somite. Orthologous to human PRKAR1A (protein kinase cAMP-dependent type I regulatory subunit alpha).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
3 figures from Kotani et al., 2010
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
1 Figure from Kotani et al., 2010
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With prkar1aa Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
acrodysostosis Alliance Acrodysostosis 1, with or without hormone resistance 101800
Carney complex Alliance Carney complex, type 1 160980
primary pigmented nodular adrenocortical disease Alliance Pigmented nodular adrenocortical disease, primary, 1 610489
Adrenocortical tumor, somatic
Myxoma, intracardiac 255960
Associated With prkar1aa Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR018488 Cyclic nucleotide-binding, conserved site
Domain IPR000595 Cyclic nucleotide-binding domain
Domain IPR003117 cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain
Family IPR012198 cAMP-dependent protein kinase regulatory subunit
Homologous_superfamily IPR014710 RmlC-like jelly roll fold
Homologous_superfamily IPR018490 Cyclic nucleotide-binding domain superfamily
Domain Details Per Protein
Protein Length cAMP-dependent protein kinase regulatory subunit cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain Cyclic nucleotide-binding, conserved site Cyclic nucleotide-binding domain Cyclic nucleotide-binding domain superfamily RmlC-like jelly roll fold
UniProtKB:Q5I0F6 379
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-prkar1aa polyclonal Mouse
  • IHC
  • WB
1
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations