Gene

bglap

ID
ZDB-GENE-050113-4
Name
bone gamma-carboxyglutamate (gla) protein
Symbol
bglap Nomenclature History
Previous Names
  • bgp (1)
  • DrOC1 (1)
  • osteocalcin (1)
  • si:ch1073-504d15.2
Type
protein_coding_gene
Location
Chr: 3 Mapping Details/Browsers
Description
Predicted to have calcium ion binding activity and hydroxyapatite binding activity. Involved in response to mechanical stimulus. Predicted to localize to extracellular region. Human ortholog(s) of this gene implicated in osteoarthritis; osteoporosis; prostate cancer; rheumatoid arthritis; and vitamin K deficiency bleeding. Is expressed in several structures, including osteoblast; renal tubule; scale; skeletal system; and trabecular layer. Orthologous to human BGLAP (bone gamma-carboxyglutamate protein).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
38 figures from 29 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With bglap Human Ortholog
No data available
Associated With bglap Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000294 Gamma-carboxyglutamic acid-rich (GLA) domain
Family IPR039176 Osteocalcin
Homologous_superfamily IPR035972 Gamma-carboxyglutamic acid-rich (GLA) domain superfamily
Domain Details Per Protein
Protein Length Gamma-carboxyglutamic acid-rich (GLA) domain Gamma-carboxyglutamic acid-rich (GLA) domain superfamily Osteocalcin
UniProtKB:Q4G6A6 104
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-bglap polyclonal Rabbit
  • IHC
2
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations