nr1d1

ID

ZDB-GENE-050105-1

Name

nuclear receptor subfamily 1, group d, member 1

Symbol

nr1d1 Nomenclature History

Previous Names

ear1 (1)
Reverbalpha (1)
zrev-erba (1)

Type

protein_coding_gene

Location

Chr: 3 Mapping Details/Browsers

Genome Assembly

GRCz12tu

Annotation Status

Current

Description

Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and sequence-specific DNA binding activity. Acts upstream of or within autophagy; circadian regulation of gene expression; and regulation of locomotor rhythm. Located in chromatin. Is expressed in nervous system. Human ortholog(s) of this gene implicated in brain small vessel disease. Orthologous to human NR1D1 (nuclear receptor subfamily 1 group D member 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

25 figures from 12 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

ay391444 (13 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 5 figures from 2 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With nr1d1 Human Ortholog

No data available

Associated With nr1d1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000536	Nuclear hormone receptor, ligand-binding domain
Domain	IPR001628	Zinc finger, nuclear hormone receptor-type
Family	IPR001723	Nuclear hormone receptor
Family	IPR001728	Thyroid hormone receptor
Family	IPR050234	Nuclear hormone receptor family NR1 subfamily
Homologous_superfamily	IPR013088	Zinc finger, NHR/GATA-type
Homologous_superfamily	IPR035500	Nuclear hormone receptor-like domain superfamily