Gene
pitx3
- ID
- ZDB-GENE-041229-4
- Name
- paired-like homeodomain 3
- Symbol
- pitx3 Nomenclature History
- Previous Names
-
- zgc:109716
- Type
- protein_coding_gene
- Location
- Chr: 13 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within adenohypophysis development; lens fiber cell differentiation; and positive regulation of DNA-templated transcription. Predicted to be active in nucleus. Is expressed in several structures, including ectoderm; head; immature eye; nervous system; and neurogenic field. Human ortholog(s) of this gene implicated in anterior segment dysgenesis; anterior segment dysgenesis 1; cataract; cataract 11 multiple types; and cataract 9 multiple types. Orthologous to human PITX3 (paired like homeodomain 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 65 figures from 38 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:109716 (14 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-pitx3 | N/A | (3) |
| MO2-pitx3 | N/A | Shi et al., 2005 |
| MO3-pitx3 | N/A | (3) |
| MO4-pitx3 | N/A | Shi et al., 2005 |
1 - 4 of 4
Show
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| anterior segment dysgenesis 1 | Alliance | Anterior segment dysgenesis 1, multiple subtypes | 107250 |
| cataract 11 multiple types | Alliance | Cataract 11, multiple types | 610623 |
| cataract 11 multiple types | Alliance | Cataract 11, syndromic, autosomal recessive | 610623 |
1 - 3 of 3
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Homedomain-like superfamily | Homeobox, conserved site | Homeobox protein Pitx/unc30 | Homeodomain | OAR domain |
|---|---|---|---|---|---|---|---|
| UniProtKB:Q6QU75 | InterPro | 293 | |||||
| UniProtKB:A0A8M9QJL4 | InterPro | 207 | |||||
| UniProtKB:B2GRZ8 | InterPro | 293 |
1 - 3 of 3
Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(pitx3:EGFP) |
|
| 1 | (5) |
1 - 1 of 1
Show
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-183C23 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-196H17 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:109716 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:192409 | ZFIN Curated Data |
1 - 4 of 4
Show
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_205675 (1) | 1878 nt | ||
| Genomic | GenBank:CR626878 (1) | 201749 nt | ||
| Polypeptide | UniProtKB:B2GRZ8 (1) | 293 aa |
- Posner, M., Garver, T., Kaye, T., Brdicka, S., Suttle, M., Patterson, B., Farnsworth, D.R. (2024) Loss of αBa-crystallin, but not αA-crystallin, increases age-related cataract in the zebrafish lens. Experimental Eye Research. 244:109918
- Ulhaq, Z.S., Ogino, Y., Tse, W.K.F. (2024) Transcriptome alterations in sf3b4-depleted zebrafish: Insights into cataract formation in retinitis pigmentosa model. Experimental Eye Research. 240:109819
- Altbürger, C., Holzhauser, J., Driever, W. (2023) CRISPR/Cas9-based QF2 knock-in at the tyrosine hydroxylase (th) locus reveals novel th-expressing neuron populations in the zebrafish mid- and hindbrain. Frontiers in Neuroanatomy. 17:11968681196868
- Yan, C.Y., Wu, F.Y., Sun, F., Fang, Y., Zhang, R.J., Zhang, C.R., Zhang, C.X., Wang, Z., Yang, R.M., Yang, L., Dong, M., Zhang, Q.Y., Ye, X.P., Song, H.D., Zhao, S.X. (2023) The isl2a transcription factor regulates pituitary development in zebrafish. Frontiers in endocrinology. 14:920548920548
- Tang, S.L., Liang, X.F., He, S., Li, L., Alam, M.S., Wu, J. (2022) Comparative Study of the Molecular Characterization, Evolution, and Structure Modeling of Digestive Lipase Genes Reveals the Different Evolutionary Selection Between Mammals and Fishes. Frontiers in genetics. 13:909091
- Farnsworth, D., Posner, M., Miller, A. (2021) Single cell transcriptomics of the developing zebrafish lens and identification of putative controllers of lens development. Experimental Eye Research. 206:108535
- Jung, J., Kim, E., Rhee, M. (2021) Kapd Is Essential for Specification of the Dopaminergic Neurogenesis in Zebrafish Embryos. Molecules and cells. 44(4):233-244
- Fabian, P., Tseng, K.C., Smeeton, J., Lancman, J.J., Dong, P.D.S., Cerny, R., Crump, J.G. (2020) Lineage analysis reveals an endodermal contribution to the vertebrate pituitary. Science (New York, N.Y.). 370:463-467
- Hughes, G.L., Lones, M.A., Bedder, M., Currie, P.D., Smith, S.L., Pownall, M.E. (2020) Machine learning discriminates a movement disorder in a zebrafish model of Parkinson's disease. Disease models & mechanisms. 13(10):
- Wong, C.E.D., Hua, K., Monis, S., Saxena, V., Norazit, A., Noor, S.M., Ekker, M. (2020) Gdnf affects early diencephalic dopaminergic neuron development through regulation of differentiation-associated transcription factors in zebrafish. Journal of neurochemistry. 156(4):481-498
1 - 10 of 57
Show