Gene

tfr2

ID
ZDB-GENE-041220-3
Name
transferrin receptor 2
Symbol
tfr2 Nomenclature History
Previous Names
  • zgc:123043
Type
protein_coding_gene
Location
Chr: 23 Mapping Details/Browsers
Description
Predicted to have transferrin receptor activity. Involved in iron ion homeostasis. Predicted to localize to integral component of membrane. Used to study hemochromatosis type 3. Human ortholog(s) of this gene implicated in hemochromatosis and hemochromatosis type 3. Is expressed in liver. Orthologous to human TFR2 (transferrin receptor 2).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
3 figures from 3 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
3 figures from Basu et al., 2018
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With tfr2 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
hemochromatosis type 3 Alliance Hemochromatosis, type 3 604250
Associated With tfr2 Via Experimental Models
Human Disease Fish Conditions Citations
hemochromatosis type 3 tfr2f6/f6 standard conditions Basu et al., 2018
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR003137 PA domain
Domain IPR007484 Peptidase M28
Domain IPR037324 Transferrin receptor protein 1/2, PA domain
Homologous_superfamily IPR036757 Transferrin receptor-like, dimerisation domain superfamily
Homologous_superfamily IPR046450 PA domain superfamily
Domain Details Per Protein
Protein Length PA domain PA domain superfamily Peptidase M28 Transferrin receptor-like, dimerisation domain superfamily Transferrin receptor protein 1/2, PA domain
UniProtKB:A0A0G2KE94 778
UniProtKB:Q5MPX2 783
Transcripts
Genome Browsers
No data available
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-tfr2 polyclonal Rabbit
  • WB
AnaSpec
2
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations