Gene
lamb1b
- ID
- ZDB-GENE-041210-197
- Name
- laminin, beta 1b
- Symbol
- lamb1b Nomenclature History
- Previous Names
-
- si:dkey-183c16.5
- Type
- protein_coding_gene
- Location
- Chr: 4 Mapping Details/Browsers
- Description
- Predicted to enable integrin binding activity. Predicted to be involved in several processes, including axon guidance; basement membrane assembly; and substrate adhesion-dependent cell spreading. Predicted to act upstream of or within cell adhesion. Predicted to be located in basement membrane and extracellular region. Predicted to be part of laminin complex. Is expressed in several structures, including fin; heart; median fin fold; nervous system; and notochord. Human ortholog(s) of this gene implicated in autistic disorder and lissencephaly 5. Orthologous to human LAMB1 (laminin subunit beta 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 5 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| lissencephaly 5 | Alliance | Lissencephaly 5 | 615191 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | EGF-like domain | Laminin IV type B | Laminin/Netrin Extracellular Matrix | Laminin, N-terminal | Laminin-type EGF domain |
|---|---|---|---|---|---|---|---|
| UniProtKB:F1REL9 | InterPro | 1767 |
1 - 1 of 1
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
lamb1b-201
(1)
|
Ensembl | 5,573 nt | ||
| mRNA |
lamb1b-202
(1)
|
Ensembl | 5,311 nt |
1 - 2 of 2
Interactions and Pathways
No data available
Plasmids
No data available
- Cark, O., Katkat, E., Aydogdu, I., Iscan, E., Oktay, Y., Ozhan, G. (2024) tubg1 Somatic Mutants Show Tubulinopathy-Associated Neurodevelopmental Phenotypes in a Zebrafish Model. Molecular neurobiology. :
- Kolb, J., Tsata, V., John, N., Kim, K., Möckel, C., Rosso, G., Kurbel, V., Parmar, A., Sharma, G., Karandasheva, K., Abuhattum, S., Lyraki, O., Beck, T., Müller, P., Schlüßler, R., Frischknecht, R., Wehner, A., Krombholz, N., Steigenberger, B., Beis, D., Takeoka, A., Blümcke, I., Möllmert, S., Singh, K., Guck, J., Kobow, K., Wehner, D. (2023) Small leucine-rich proteoglycans inhibit CNS regeneration by modifying the structural and mechanical properties of the lesion environment. Nature communications. 14:68146814
- Zhao, N., Wang, X., Wang, T., Xu, X., Liu, Q., Li, J. (2022) Genome-Wide Identification of Laminin Family Related to Follicular Pseudoplacenta Development in Black Rockfish (Sebastes schlegelii). International Journal of Molecular Sciences. 23(18)
- Derrick, C.J., Pollitt, E.J.G., Sevilla Uruchurtu, A.S., Hussein, F., Grierson, A.J., Noël, E.S. (2021) Lamb1a regulates atrial growth by limiting second heart field addition during zebrafish heart development. Development (Cambridge, England). 148(20)
- Roan, H.Y., Tseng, T.L., Chen, C.H. (2021) Whole-body clonal mapping identifies giant dominant clones in zebrafish skin epidermis. Development (Cambridge, England). 148(18)
- Marchi, D., Santhakumar, K., Markham, E., Li, N., Storbeck, K.H., Krone, N., Cunliffe, V.T., van Eeden, F.J.M. (2020) Bidirectional crosstalk between Hypoxia-Inducible Factor and glucocorticoid signalling in zebrafish larvae. PLoS Genetics. 16:e1008757
- Nicholas, C., Weaver, M., Piedade, W.P., Vocking, O., Famulski, J.K. (2019) Temporal characterization of optic fissure basement membrane composition suggests nidogen may be an initial target of remodeling. Developmental Biology. 452(1):43-54
- Hu, B., Gao, Y., Davies, L., Woo, S., Topczewski, J., Jessen, J.R., Lin, F. (2018) Glypican 4 and Mmp14 interact in regulating the migration of anterior endodermal cells by limiting extracellular matrix deposition. Development (Cambridge, England). 145(17):
- Chen, C.H., Merriman, A.F., Savage, J., Willer, J., Wahlig, T., Katsanis, N., Yin, V.P., Poss, K.D. (2015) Transient laminin beta 1a Induction Defines the Wound Epidermis during Zebrafish Fin Regeneration. PLoS Genetics. 11:e1005437
- Lambert, M.J., Olsen, K.G., Cooper, C.D. (2014) Gene duplication followed by exon structure divergence substitutes for alternative splicing in zebrafish. Gene. 546(2):271-6
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