ZFIN is now using GRCz12tu for Genomic Data
Gene
pmch
- ID
- ZDB-GENE-041210-150
- Name
- pro-melanin-concentrating hormone
- Symbol
- pmch Nomenclature History
- Previous Names
-
- pmch2 (1)
- si:ch211-260p3.3
- Type
- protein_coding_gene
- Location
- Chr: 4 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable type 1 melanin-concentrating hormone receptor binding activity. Predicted to be involved in negative regulation of dopaminergic synaptic transmission. Is expressed in brain; female organism; male organism; and neurons. Orthologous to several human genes including PMCH (pro-melanin concentrating hormone).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 13 figures from 8 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Family | IPR005456 | Pre-pro melanin-concentrating hormone |
1 - 1 of 1
Domain Details Per Protein
| Protein | Additional Resources | Length | Pre-pro melanin-concentrating hormone |
|---|---|---|---|
| UniProtKB:C9W8C3 | InterPro | 151 |
1 - 1 of 1
Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-pmch | polyclonal | Rabbit |
|
Phoenix Pharmaceuticals, Inc.
|
6 | ||
| Ab2-pmch | polyclonal | Rabbit |
|
Sigma-Aldrich
|
1 |
1 - 2 of 2
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(-5pmch:epNTR-TagRFPT,cryaa:mCherry) |
|
| 1 | Leung et al., 2019 | |
| Tg(hsp70l:pmch) |
|
| 1 | Madelaine et al., 2020 | |
| Tg(pmch:EGFP) |
|
| 1 | Madelaine et al., 2020 | |
| Tg(pmch:GAL4-VP16) |
|
| 1 | Zebrafish Nomenclature Committee |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-260P3 | ZFIN Curated Data |
1 - 1 of 1
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| Type | Accession # | Genome Assembly | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001202542 (1) | 593 nt | ||
| Genomic | GenBank:BX510924 (1) | 143251 nt | ||
| Polypeptide | UniProtKB:C9W8C3 (1) | 151 aa |
- Zebrafish Nomenclature Committee (2025) Nomenclature Data Curation (2025). Nomenclature Committee Submission.
- Zebrafish Nomenclature Committee (2024) Nomenclature Data Curation (2024). Nomenclature Committee Submission.
- Lin, C.Y., Yeh, K.Y., Lai, H.H., Her, G.M. (2023) AgRP Neuron-Specific Ablation Represses Appetite, Energy Intake, and Somatic Growth in Larval Zebrafish. Biomedicines. 11(2):
- Ahi, E.P., Brunel, M., Tsakoumis, E., Chen, J., Schmitz, M. (2022) Appetite regulating genes in zebrafish gut; a gene expression study. PLoS One. 17:e0255201
- de Alba, G., Carrillo, S., Sánchez-Vázquez, F.J., López-Olmeda, J.F. (2022) Combined blue light and daily thermocycles enhance zebrafish growth and development. Journal of experimental zoology. Part A, Ecological and integrative physiology. 337(5):501-515
- Hsieh, Y.W., Tsai, Y.W., Lai, H.H., Lai, C.Y., Lin, C.Y., Her, G.M. (2021) Depletion of Alpha-Melanocyte-Stimulating Hormone Induces Insatiable Appetite and Gains in Energy Reserves and Body Weight in Zebrafish. Biomedicines. 9(8):
- Ikeda, A., Komamizu, M., Hayashi, A., Yamasaki, C., Okada, K., Kawabe, M., Komatsu, M., Shiozaki, K. (2021) Neu1 deficiency induces abnormal emotional behavior in zebrafish. Scientific Reports. 11:13477
- Kawabe, M., Hayashi, A., Komatsu, M., Inui, A., Shiozaki, K. (2021) Ninjinyoeito improves anxiety behavior in neuropeptide Y deficient zebrafish. Neuropeptides. 87:102136
- Madelaine, R., Ngo, K.J., Skariah, G., Mourrain, P. (2020) Genetic deciphering of the antagonistic activities of the melanin-concentrating hormone and melanocortin pathways in skin pigmentation. PLoS Genetics. 16:e1009244
- Schredelseker, T., Veit, F., Dorsky, R.I., Driever, W. (2020) Bsx Is Essential for Differentiation of Multiple Neuromodulatory Cell Populations in the Secondary Prosencephalon. Frontiers in neuroscience. 14:525
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