Gene

nr2e3

ID
ZDB-GENE-041114-63
Name
nuclear receptor subfamily 2, group E, member 3
Symbol
nr2e3 Nomenclature History
Previous Names
  • NR2D2 (1)
  • fj55b07
  • PNR (1)
  • wu:fj55b07
  • zgc:103631
Type
protein_coding_gene
Location
Chr: 25 Mapping Details/Browsers
Description
Predicted to have DNA-binding transcription factor activity and RNA polymerase II regulatory region sequence-specific DNA binding activity. Involved in pineal gland development. Localizes to nucleus. Human ortholog(s) of this gene implicated in enhanced S-cone syndrome and retinitis pigmentosa 37. Is expressed in several structures, including diencephalon; optic vesicle; presumptive diencephalon; presumptive neural retina; and retina. Orthologous to human NR2E3 (nuclear receptor subfamily 2 group E member 3).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
38 figures from 18 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
5 figures from 2 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With nr2e3 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
enhanced S-cone syndrome Alliance Enhanced S-cone syndrome 268100
retinitis pigmentosa 37 Alliance Retinitis pigmentosa 37 611131
Associated With nr2e3 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000536 Nuclear hormone receptor, ligand-binding domain
Domain IPR001628 Zinc finger, nuclear hormone receptor-type
Family IPR001723 Nuclear hormone receptor
Homologous_superfamily IPR013088 Zinc finger, NHR/GATA-type
Homologous_superfamily IPR035500 Nuclear hormone receptor-like domain superfamily
Domain Details Per Protein
Protein Length Nuclear hormone receptor Nuclear hormone receptor, ligand-binding domain Nuclear hormone receptor-like domain superfamily Zinc finger, NHR/GATA-type Zinc finger, nuclear hormone receptor-type
UniProtKB:Q5U3F3 419
UniProtKB:A0FIJ9 348
UniProtKB:F1QGF3 426
UniProtKB:A8KBN2 344
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-nr2e3 polyclonal Rabbit
  • IHC
4
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations