Gene
sele
- ID
- ZDB-GENE-041014-221
- Name
- selectin E
- Symbol
- sele Nomenclature History
- Previous Names
-
- si:ch211-260g14.8 (1)
- Type
- protein_coding_gene
- Location
- Chr: 20 Mapping Details/Browsers
- Description
- Predicted to enable oligosaccharide binding activity and sialic acid binding activity. Predicted to be involved in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; leukocyte tethering or rolling; and response to cytokine. Predicted to act upstream of or within cell adhesion. Predicted to be located in plasma membrane. Predicted to be active in external side of plasma membrane and extracellular space. Is expressed in intermediate cell mass of mesoderm; posterior cardinal vein; and trunk. Human ortholog(s) of this gene implicated in several diseases, including IgA glomerulonephritis; atopic dermatitis; cerebrovascular disease (multiple); coronary artery disease (multiple); and inflammatory bowel disease (multiple). Orthologous to several human genes including SELP (selectin P).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 5 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR018378 | C-type lectin, conserved site |
| Domain | IPR000436 | Sushi/SCR/CCP domain |
| Domain | IPR000742 | EGF-like domain |
| Domain | IPR001304 | C-type lectin-like |
| Domain | IPR033991 | Selectin, C-type lectin-like domain |
| Family | IPR002396 | Selectin superfamily |
| Family | IPR050350 | Complement & Cell Adhesion Regulators |
| Family | IPR051277 | SEZ6/CSMD/C4BPB Neuronal & Immune Regulators |
| Homologous_superfamily | IPR016186 | C-type lectin-like/link domain superfamily |
| Homologous_superfamily | IPR016187 | C-type lectin fold |
| Homologous_superfamily | IPR035976 | Sushi/SCR/CCP superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Complement & Cell Adhesion Regulators | C-type lectin, conserved site | C-type lectin fold | C-type lectin-like | C-type lectin-like/link domain superfamily | EGF-like domain | Selectin, C-type lectin-like domain | Selectin superfamily | SEZ6/CSMD/C4BPB Neuronal & Immune Regulators | Sushi/SCR/CCP domain | Sushi/SCR/CCP superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M3AKX4 | InterPro | 871 | |||||||||||
| UniProtKB:A0A8M3B473 | InterPro | 687 | |||||||||||
| UniProtKB:A0A8M3ALL6 | InterPro | 561 | |||||||||||
| UniProtKB:A0A8M6Z2N9 | InterPro | 561 | |||||||||||
| UniProtKB:A0A8M1NL34 | InterPro | 872 | |||||||||||
| UniProtKB:A0A8M6YUT5 | InterPro | 561 | |||||||||||
| UniProtKB:A0A8M3AWB7 | InterPro | 561 |
Interactions and Pathways
No data available
Plasmids
No data available