Gene
sele
- ID
- ZDB-GENE-041014-221
- Name
- selectin E
- Symbol
- sele Nomenclature History
- Previous Names
-
- si:ch211-260g14.8 (1)
- Type
- protein_coding_gene
- Location
- Chr: 20 Mapping Details/Browsers
- Description
- Predicted to enable oligosaccharide binding activity and sialic acid binding activity. Predicted to be involved in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; leukocyte tethering or rolling; and response to cytokine. Predicted to act upstream of or within cell adhesion. Predicted to be located in plasma membrane. Predicted to be active in external side of plasma membrane and extracellular space. Is expressed in intermediate cell mass of mesoderm; posterior cardinal vein; and trunk. Human ortholog(s) of this gene implicated in several diseases, including IgA glomerulonephritis; atopic dermatitis; cerebrovascular disease (multiple); coronary artery disease (multiple); and inflammatory bowel disease (multiple). Orthologous to several human genes including SELP (selectin P).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 5 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Allele | Type | Localization | Consequence | Mutagen | Supplier |
---|---|---|---|---|---|
sa139 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa11522 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa15565 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa39289 | Allele with one point mutation | Unknown | Splice Site | ENU |
1 - 4 of 4
Show
No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Additional Resources | Length | Complement & Cell Adhesion Regulators | C-type lectin, conserved site | C-type lectin fold | C-type lectin-like | C-type lectin-like/link domain superfamily | EGF-like domain | Selectin, C-type lectin-like domain | Selectin superfamily | SEZ6/CSMD/C4BPB Neuronal & Immune Regulators | Sushi/SCR/CCP domain | Sushi/SCR/CCP superfamily |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
UniProtKB:A0A8M3AKX4 | InterPro | 871 | |||||||||||
UniProtKB:A0A8M3B473 | InterPro | 687 | |||||||||||
UniProtKB:A0A8M3ALL6 | InterPro | 561 | |||||||||||
UniProtKB:A0A8M6Z2N9 | InterPro | 561 | |||||||||||
UniProtKB:A0A8M1NL34 | InterPro | 872 |
1 - 5 of 7 Show all
Interactions and Pathways
No data available
Plasmids
No data available
Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
---|---|---|---|---|---|
Tg(sele:prkcda-2A-mCherry) |
|
| 1 | Binder et al., 2023 |
1 - 1 of 1
Show
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | CH211-260G14 | ZFIN Curated Data | |
Contained in | BAC | DKEY-51E6 | ZFIN Curated Data | |
Encodes | cDNA | MGC:175269 | ZFIN Curated Data |
1 - 3 of 3
Show
Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_001130598 (1) | 4574 nt | ||
Genomic | GenBank:BX296562 (1) | 129328 nt | ||
Polypeptide | UniProtKB:A0A8M1NL34 (1) | 872 aa |
- Binder, V., Li, W., Faisal, M., Oyman, K., Calkins, D.L., Shaffer, J., Teets, E.M., Sher, S., Magnotte, A., Belardo, A., Deruelle, W., Gregory, T.C., Orwick, S., Hagedorn, E.J., Perlin, J.R., Avagyan, S., Lichtig, A., Barrett, F., Ammerman, M., Yang, S., Zhou, Y., Carson, W.E., Shive, H.R., Blachly, J.S., Lapalombella, R., Zon, L.I., Blaser, B.W. (2023) Microenvironmental control of hematopoietic stem cell fate via CXCL8 and protein kinase C. Cell Reports. 42:112528112528
- Kondo, M., Kimura, K., Kobayashi-Sun, J., Yamamori, S., Taniguchi, M., Traver, D., Kobayashi, I. (2023) The sinusoidal hematopoietic niche is formed by Jam1a via Notch signaling in the zebrafish kidney. iScience. 26:106508106508
- Torraca, V., White, R.J., Sealy, I.M., Mazon-Moya, M., Duggan, G., Willis, A., Busch-Nentwich, E.M., Mostowy, S. (2023) Transcriptional profiling of zebrafish identifies host factors controlling susceptibility to Shigella flexneri. Disease models & mechanisms. 17(1):
- Wang, W., Zhang, J., Li, Z., Gu, J., Qin, J., Li, J., Zhang, X., Ru, S. (2021) Bisphenol S exposure accelerates the progression of atherosclerosis in zebrafish embryo-larvae. Journal of hazardous materials. 426:128042
- Wang, W., Ru, S., Wang, L., Qin, J., Ru, Y., Zhang, J., Zhang, X. (2020) Bisphenol S induces ectopic angiogenesis in embryos via VEGFR2 signaling, leading to lipid deposition in blood vessels of larval zebrafish. Environmental science & technology. 54(11):6822-6831
- Chestnut, B., Sumanas, S. (2019) Zebrafish etv2 knock-in line labels vascular endothelial and blood progenitor cells. Developmental Dynamics : an official publication of the American Association of Anatomists. 249(2):245-261
- Tang, Q., Iyer, S., Lobbardi, R., Moore, J.C., Chen, H., Lareau, C., Hebert, C., Shaw, M.L., Neftel, C., Suva, M.L., Ceol, C.J., Bernards, A., Aryee, M., Pinello, L., Drummond, I.A., Langenau, D.M. (2017) Dissecting hematopoietic and renal cell heterogeneity in adult zebrafish at single-cell resolution using RNA sequencing. The Journal of experimental medicine. 214(10):2875-2887
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Esain, V., Kwan, W., Carroll, K.J., Cortes, M., Liu, S.Y., Frechette, G.M., Sheward, L.M., Nissim, S., Goessling, W., North, T.E. (2015) Cannabinoid Receptor-2 Regulates Embryonic Hematopoietic Stem Cell Development via PGE2 and P-selectin Activity. Stem cells (Dayton, Ohio). 33(8):2596-612
- Ren, D.L., Sun, A.A., Li, Y.J., Chen, M., Ge, S.C., Hu, B. (2015) Exogenous melatonin inhibits neutrophil migration through suppression of ERK activation. The Journal of endocrinology. 227(1):49-60
1 - 10 of 12
Show