ZFIN is now using GRCz12tu for Genomic Data
Gene
ppp1r12a
- ID
- ZDB-GENE-041011-3
- Name
- protein phosphatase 1, regulatory subunit 12A
- Symbol
- ppp1r12a Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 4 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable 14-3-3 protein binding activity; enzyme inhibitor activity; and myosin phosphatase regulator activity. Acts upstream of or within several processes, including actin filament bundle organization; convergent extension involved in axis elongation; and nervous system development. Located in cytoplasm. Is expressed in several structures, including digestive system; endoderm; mesoderm; myotome; and nervous system. Orthologous to several human genes including PPP1R12A (protein phosphatase 1 regulatory subunit 12A).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 8 figures from 8 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 36 figures from 12 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Genitourinary and/or/brain malformation syndrome | 618820 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR031775 | cGMP-dependent protein kinase, interacting domain |
| Family | IPR017401 | Protein phosphatase 1 regulatory subunit 12A/B/C |
| Family | IPR051226 | Protein Phosphatase 1 Regulatory Subunit |
| Homologous_superfamily | IPR036770 | Ankyrin repeat-containing domain superfamily |
| Repeat | IPR002110 | Ankyrin repeat |
Domain Details Per Protein
| Protein | Additional Resources | Length | Ankyrin repeat | Ankyrin repeat-containing domain superfamily | cGMP-dependent protein kinase, interacting domain | Protein Phosphatase 1 Regulatory Subunit | Protein phosphatase 1 regulatory subunit 12A/B/C |
|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M9PH66 | InterPro | 1065 | |||||
| UniProtKB:Q6DRG7 | InterPro | 1049 | |||||
| UniProtKB:A0A8M6YX05 | InterPro | 1081 | |||||
| UniProtKB:A0A8M9QB53 | InterPro | 1097 | |||||
| UniProtKB:A0A8M9PUD2 | InterPro | 1049 | |||||
| UniProtKB:A0A8M9Q0E6 | InterPro | 1001 | |||||
| UniProtKB:A0A8M9Q5V2 | InterPro | 1090 | |||||
| UniProtKB:A0AC58J6D0 | InterPro | 1017 | |||||
| UniProtKB:A0AC58J6D1 | InterPro | 869 | |||||
| UniProtKB:A0AC58J6D2 | InterPro | 1042 | |||||
| UniProtKB:A0AC58J6D6 | InterPro | 1058 | |||||
| UniProtKB:A0AC58J6E1 | InterPro | 917 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
ppp1r12a-201
(1)
|
Ensembl | 4,846 nt | ||
| mRNA | ppp1r12a-tv201 (1) | 3,313 nt | |||
| mRNA | ppp1r12a-tv202 (1) | 3,032 nt |
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers