Gene

polr2a

ID
ZDB-GENE-041008-78
Name
RNA polymerase II subunit A
Symbol
polr2a Nomenclature History
Previous Names
  • im:7136071 (1)
Type
protein_coding_gene
Location
Chr: 12 Mapping Details/Browsers
Description
Predicted to enable DNA binding activity; metal ion binding activity; and nucleotidyltransferase activity. Predicted to contribute to DNA-directed RNA polymerase activity. Predicted to be involved in mRNA transcription by RNA polymerase II. Predicted to act upstream of or within transcription by RNA polymerase II. Predicted to be located in chromosome; cytoplasm; and nucleoplasm. Predicted to be part of RNA polymerase II, core complex. Is expressed in blastomere. Orthologous to human POLR2A (RNA polymerase II subunit A).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
3 figures from 3 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
1 - 7 of 7
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Sequence Targeting Reagents
1 - 9 of 9
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Human Disease
Associated With polr2a Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Neurodevelopmental disorder with hypotonia and variable intellectual and behavioral abnormalities 618603
1 - 1 of 1
Associated With polr2a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000722 RNA polymerase, alpha subunit
Domain IPR006592 RNA polymerase, N-terminal
Domain IPR007066 RNA polymerase Rpb1, domain 3
Domain IPR007073 RNA polymerase Rpb1, domain 7
Domain IPR007075 RNA polymerase Rpb1, domain 6
1 - 5 of 14 Show all
Domain Details Per Protein
Protein Additional Resources Length DNA-directed RNA polymerase, subunit beta-prime RNA polymerase, alpha subunit RNA polymerase II, heptapeptide repeat, eukaryotic RNA polymerase, N-terminal RNA polymerase Rpb1, clamp domain superfamily RNA polymerase Rpb1, domain 1 RNA polymerase Rpb1, domain 3 RNA polymerase Rpb1, domain 3 superfamily RNA polymerase Rpb1, domain 4 RNA polymerase Rpb1, domain 5 RNA polymerase Rpb1, domain 6 RNA polymerase Rpb1, domain 7 RNA polymerase Rpb1, domain 7 superfamily RNA polymerase Rpb1, funnel domain superfamily
UniProtKB:A0A0R4IMS9 InterPro 1965
1 - 1 of 1
Transcripts
Genome Browsers
Genome Build: GRCz11Chromosome: 12
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA polr2a-201 (1) Ensembl 8,182 nt
1 - 1 of 1
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-polr2a monoclonal IgG2a Mouse
  • IHC
Santa Cruz Biotechnology, Inc.
Covance
9
Ab2-polr2a monoclonal IgG1 Mouse
Santa Cruz Biotechnology, Inc.
Covance
4
1 - 2 of 2
Plasmids
No data available
Constructs
No data available
Marker Relationships
Relationship Marker Type Marker Accession Numbers Citations
Contained inBACCH211-222B21ZFIN Curated Data
Contained inBACDKEY-38P12ZFIN Curated Data
EncodesESTIMAGE:7136071Thisse et al., 2004
EncodesESTwz12613
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Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Species Symbol Chromosome Accession # Evidence
HumanPOLR2A17
Amino acid sequence comparison (1)
Conserved genome location (synteny) (1)
MousePolr2a11
Amino acid sequence comparison (1)
Conserved genome location (synteny) (1)
Citations
1 - 5 of 5
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