Gene
polr2a
- ID
- ZDB-GENE-041008-78
- Name
- RNA polymerase II subunit A
- Symbol
- polr2a Nomenclature History
- Previous Names
-
- im:7136071 (1)
- Type
- protein_coding_gene
- Location
- Chr: 12 Mapping Details/Browsers
- Description
- Predicted to enable DNA binding activity; metal ion binding activity; and nucleotidyltransferase activity. Predicted to contribute to DNA-directed RNA polymerase activity. Predicted to be involved in mRNA transcription by RNA polymerase II. Predicted to act upstream of or within transcription by RNA polymerase II. Predicted to be located in chromosome; cytoplasm; and nucleoplasm. Predicted to be part of RNA polymerase II, core complex. Is expressed in blastomere. Orthologous to human POLR2A (RNA polymerase II subunit A).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7136071 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Neurodevelopmental disorder with hypotonia and variable intellectual and behavioral abnormalities | 618603 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000722 | RNA polymerase, alpha subunit |
| Domain | IPR006592 | RNA polymerase, N-terminal |
| Domain | IPR007066 | RNA polymerase Rpb1, domain 3 |
| Domain | IPR007073 | RNA polymerase Rpb1, domain 7 |
| Domain | IPR007075 | RNA polymerase Rpb1, domain 6 |
| Domain | IPR007080 | RNA polymerase Rpb1, domain 1 |
| Domain | IPR007081 | RNA polymerase Rpb1, domain 5 |
| Domain | IPR007083 | RNA polymerase Rpb1, domain 4 |
| Family | IPR045867 | DNA-directed RNA polymerase, subunit beta-prime |
| Homologous_superfamily | IPR038120 | RNA polymerase Rpb1, funnel domain superfamily |
| Homologous_superfamily | IPR038593 | RNA polymerase Rpb1, domain 7 superfamily |
| Homologous_superfamily | IPR042102 | RNA polymerase Rpb1, domain 3 superfamily |
| Homologous_superfamily | IPR044893 | RNA polymerase Rpb1, clamp domain superfamily |
| Repeat | IPR000684 | RNA polymerase II, heptapeptide repeat, eukaryotic |
Domain Details Per Protein
| Protein | Additional Resources | Length | DNA-directed RNA polymerase, subunit beta-prime | RNA polymerase, alpha subunit | RNA polymerase II, heptapeptide repeat, eukaryotic | RNA polymerase, N-terminal | RNA polymerase Rpb1, clamp domain superfamily | RNA polymerase Rpb1, domain 1 | RNA polymerase Rpb1, domain 3 | RNA polymerase Rpb1, domain 3 superfamily | RNA polymerase Rpb1, domain 4 | RNA polymerase Rpb1, domain 5 | RNA polymerase Rpb1, domain 6 | RNA polymerase Rpb1, domain 7 | RNA polymerase Rpb1, domain 7 superfamily | RNA polymerase Rpb1, funnel domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A0R4IMS9 | InterPro | 1965 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
polr2a-201
(1)
|
Ensembl | 8,182 nt |
Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-polr2a | monoclonal | IgG2a | Mouse |
|
Santa Cruz Biotechnology, Inc.
Covance |
9 | |
| Ab2-polr2a | monoclonal | IgG1 | Mouse |
|
Santa Cruz Biotechnology, Inc.
Covance |
4 |
Plasmids
No data available