ZFIN is now using GRCz12tu for Genomic Data
Gene
mep1a.1
- ID
- ZDB-GENE-041001-209
- Name
- meprin A, alpha (PABA peptide hydrolase), tandem duplicate 1
- Symbol
- mep1a.1 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 20 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable metalloendopeptidase activity. Predicted to be located in membrane. Predicted to be active in extracellular space. Is expressed in several structures, including brush border epithelial cell; digestive system; epidermis; gill; and heart. Orthologous to human MEP1A (meprin A subunit alpha).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Schütte et al., 2010
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la021600Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa6643 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa10535 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa13188 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa17730 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa31046 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa43495 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Concanavalin A-like lectin/glucanase domain superfamily | MAM domain | MATH/TRAF domain | Metallopeptidase, catalytic domain superfamily | Peptidase M12A | Peptidase, metallopeptidase | TRAF-like |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q5RHM1 | InterPro | 598 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
mep1a.1-201
(1)
|
Ensembl | 1,983 nt | ||
| ncRNA |
mep1a.1-002
(1)
|
Ensembl | 664 nt |
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Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-mep1a.1 | polyclonal |
|
1 |
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Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-30J22 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:136668 | ZFIN Curated Data |
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| Type | Accession # | Genome Assembly | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001030281 (1) | 2005 nt | ||
| Genomic | GenBank:BX510920 (1) | 220240 nt | ||
| Polypeptide | UniProtKB:Q5RHM1 (1) | 598 aa |
- Comparative Orthology
- Alliance
- Gene Tree
- Ensembl
- Note
- This gene and mep1a.2 (ZDB-GENE-041001-208) are located next to each other in the genome and appear to be the result of a tandem duplication. The tandem duplicates appear to be the orthologs of human MEP1A and mouse Mep1a based on amino acid identity and conserved location.
- Jiang, J., Chen, L., Wu, S., Lv, L., Liu, X., Wang, Q., Zhao, X. (2020) Effects of difenoconazole on hepatotoxicity, lipid metabolism and gut microbiota in zebrafish (Danio rerio). Environmental pollution (Barking, Essex : 1987). 265:114844
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Mohseny, A.B., Xiao, W., Carvalho, R., Spaink, H.P., Hogendoorn, P.C., and Cleton-Jansen, AM. (2012) An osteosarcoma zebrafish model implicates Mmp-19 and Ets-1 as well as reduced host immune response in angiogenesis and migration. The Journal of pathology. 227(2):245-253
- Schütte, A., Hedrich, J., Stöcker, W., and Becker-Pauly, C. (2010) Let It Flow: Morpholino Knockdown in Zebrafish Embryos Reveals a Pro-Angiogenic Effect of the Metalloprotease Meprin alpha(2). PLoS One. 5(1):e8835
- Huxley-Jones, J., Clarke, T.K., Beck, C., Toubaris, G., Robertson, D.L., and Boot-Handford, R.P. (2007) The evolution of the vertebrate metzincins; insights from Ciona intestinalis and Danio rerio. BMC Evolutionary Biology. 7(1):63
- Schutte, A., Lottaz, D., Sterchi, E.E., Stocker, W., and Becker-Pauly, C. (2007) Two alpha subunits and one beta subunit of meprin zinc-endopeptidases are differentially expressed in the zebrafish Danio rerio. Biological chemistry. 388(5):523-531
- Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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